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Description:
7,8-dihydro-8-oxoguanine triphosphatase (EC 3.1.6.-) (8-oxo-dGTPase)(Nucleoside diphosphate-linked moiety X motif 1) (Nudix motif 1).
Molecular weight: 17908
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
07-FEB-2006, entry version 36.
Phylogenetic order:
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Sciurognathi Muroidea Muridae Murinae Mus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein 8ODP_MOUSE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | D49956 | BAA08711.1 | - |
| EMBL | D88356 | BAA19866.1 | - |
| PIR | I49446 | I49446. | |
| SMR | P53368 | 1-155.1 | |
| Ensembl | ENSMUSG00000036639 | Mus musculus.1 | |
| MGI | MGI:109280 | Nudt1.1 | |
| GO | GO:0005615 | C:extracellular space | TAS. |
| GO | GO:0008413 | F:8-oxo-7,8-dihydroguanine triphosphatase act... | IDA. |
| GO | GO:0006203 | P:dGTP catabolism | IDA. |
| InterPro | IPR003563 | 8Ox_triPHTase. | |
| InterPro | IPR000086 | NUDIX_hydrolase. | |
| Pfam | PF00293 | NUDIX | 1. |
| PRINTS | PR01403 | 8OXTPHPHTASE. | |
| PRINTS | PR00502 | NUDIXFAMILY. | |
| PROSITE | PS00893 | NUDIX | 1. |
Keywords:
Hydrolase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=129/Sv;
RX MEDLINE=96029697; PubMed=7592783; DOI=10.1074/jbc.270.43.25942;
RA Kakuma T., Nishida J., Tsuzuki T., Sekiguchi M.;
RT "Mouse MTH1 protein with 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-
RT triphosphatase activity that prevents transversion mutation. cDNA
RT cloning and tissue distribution.";
RL J. Biol. Chem. 270:25942-25948(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=129/Sv;
RX MEDLINE=97166235; PubMed=9013634; DOI=10.1074/jbc.272.6.3766;
RA Igarashi H., Tsuzuki T., Kakuma T., Tominaga Y., Sekiguchi M.;
RT "Organization and expression of the mouse MTH1 gene for preventing
RT transversion mutation.";
RL J. Biol. Chem. 272:3766-3772(1997).
Feature:
CHAIN 1 156 7,8-dihydro-8-oxoguanine triphosphatase.
/FTId=PRO_0000057100.
MOTIF 37 58 Nudix box.
Comments:
-!- FUNCTION: Antimutagenic. Responsible for preventing
misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G
transversions.
-!- CATALYTIC ACTIVITY: 8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate.
-!- SIMILARITY: Belongs to the Nudix hydrolase family.
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Sequence length: 156
MSTSRLYTLV LVLQPQRVLL GMKKRGFGAG RWNGFGGKVQ EGETIEDGAK RELLEESGLS
VDTLHKVGHI SFEFVGSPEL MDVHIFSADH VHGTPTESEE MRPQWFQLDQ IPFADLWPDD
SYWFPLLLQK KKFCGHFKFQ DQDTILSYSL REVDSF