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Description:
Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicaseATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1alpha-interacting protein) (HP1-BP38 protein).
Molecular weight: 2786
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 2.
07-MAR-2006, entry version 51.
Phylogenetic order:
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Sciurognathi Muroidea Muridae Murinae Mus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein ATRX_MOUSE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AF026032 | AAC08741.1 | - |
| EMBL | X99643 | CAA67962.1 | - |
| HSSP | Q14839 | 1MM2 | |
| Ensembl | ENSMUSG00000031229 | Mus musculus.1 | |
| MGI | MGI:103067 | Atrx.1 | |
| GO | GO:0000792 | C:heterochromatin | IDA. |
| GO | GO:0000228 | C:nuclear chromosome | IDA. |
| GO | GO:0003682 | F:chromatin binding | IDA. |
| GO | GO:0030900 | P:forebrain development | IMP. |
| InterPro | IPR011545 | DEAD/DEAH_N. | |
| InterPro | IPR001650 | Helicase_C. | |
| InterPro | IPR000330 | SNF2_N. | |
| InterPro | IPR001965 | Znf_PHD. | |
| Pfam | PF00271 | Helicase_C | 1. |
| Pfam | PF00176 | SNF2_N | 1. |
| SMART | SM00487 | DEXDc | 1. |
| SMART | SM00490 | HELICc | 1. |
| PROSITE | PS01359 | ZF_PHD_1 | FALSE_NEG. |
| PROSITE | PS50016 | ZF_PHD_2 | FALSE_NEG. |
Keywords:
ATP-binding; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase; Metal-binding; Nuclear protein; Nucleotide-binding; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX MEDLINE=98213653; PubMed=9545503; DOI=10.1007/s003359900781;
RA Picketts D.J., Tastan A.O., Higgs D.R., Gibbons R.J.;
RT "Comparison of the human and murine ATRX gene identifies highly
RT conserved, functionally important domains.";
RL Mamm. Genome 9:400-403(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 325-1176.
RX MEDLINE=97133299; PubMed=8978696;
RA le Douarin B., Nielsen A.L., Garnier J.-M., Ichinose H.,
RA Jeanmougin F., Losson R., Chambon P.;
RT "A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic
RT control of transcription by nuclear receptors.";
RL EMBO J. 15:6701-6715(1996).
RN [3]
RP SUBCELLULAR LOCATION, AND ASSOCIATION WITH PERICENTROMERIC
RP HETEROCHROMATIN.
RX MEDLINE=20040663; PubMed=10570185; DOI=10.1073/pnas.96.24.13983;
RA McDowell T.L., Gibbons R.J., Sutherland H., O'Rourke D.M.,
RA Bickmore W.A., Pombo A., Turley H., Gatter K., Picketts D.J.,
RA Buckle V.J., Chapman L., Rhodes D., Higgs D.R.;
RT "Localization of a putative transcriptional regulator (ATRX) at
RT pericentromeric heterochromatin and the short arms of acrocentric
RT chromosomes.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:13983-13988(1999).
Feature:
CHAIN 1 2476 Transcriptional regulator ATRX.
/FTId=PRO_0000074303.
ZN_FING 219 267 PHD-type.
NP_BIND 1579 1586 ATP (Potential).
MOTIF 573 586 PxVxL motif.
MOTIF 1704 1707 DEGH box.
COMPBIAS 319 322 Poly-Ser.
COMPBIAS 735 738 Poly-Ser.
COMPBIAS 1001 1004 Poly-Glu.
COMPBIAS 1130 1135 Poly-Ser.
COMPBIAS 1182 1185 Poly-Ser.
COMPBIAS 1238 1245 Poly-Asp.
COMPBIAS 1484 1487 Poly-Glu.
COMPBIAS 1924 1931 Poly-Ser.
COMPBIAS 2205 2208 Poly-Lys.
COMPBIAS 2245 2248 Poly-Glu.
COMPBIAS 2403 2408 Poly-Gln.
Comments:
-!- FUNCTION: Could be a global transcriptional regulator. Modifies
gene expression by affecting chromatin.
-!- SUBUNIT: Probably binds EZH2. Binds annexin V in a calcium and
phosphatidylcholine/phosphatidylserine-dependent manner. Interacts
directly with CBX5 via the PxVxL motif (By similarity).
-!- SUBCELLULAR LOCATION: Nuclear. Associated with pericentromeric
heterochromatin during interphase and mitosis, probably by
interacting with HP1.
-!- DOMAIN: Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is
required for interaction with chromoshadow domains. This motif
requires additional residues -7, -6, +4 and +5 of the central Val
which contact the chromoshadow domain.
-!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
-!- SIMILARITY: Contains 1 helicase domain.
-!- SIMILARITY: Contains 1 PHD-type zinc finger.
-!- SIMILARITY: Contains 1 SNF2_N domain.
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Sequence length: 2476
MTAEPMSGNK LSTLVQKLHD FLAHSSEESE ETCSSPRLVM NQSTDKICGS GLNSDMMENN
KEEGASTSEK SRSSGSSRSK RKPSIVTKYV ESDDEKPTDE NVNEKAATEN SENDITMQSL
PKGTVIVQPE PVLNEDKDDF KGPEFRSRSK MKADNLIKRG EDGLHGIVSC TACGQQVNHF
QKDSIYRHPS LKVLICKNCF KYYMSDDISR DSDGMDEQCR WCAEGGNLIC CDFCHNAFCK
KCILRNLGRK ELSTIMDENN QWYCYICQPE PLLDLVTACN SVFENLEQLL QQNKKKIKVD
SEKTSKVCDQ TSKFSPKKSS SSCNGEEKKL EESCSGSVSS TYSHSALSVP KEMIKKTTKL
IETTSNMNSS YIKFLKQAAD NSEMTSAMKL CQLKSFKSVL DDIKKAHLAL EEDLNSEIQA
LDDVHKEKNT KDLKSTDAKS ETKLGKGEKS YSTEKREFLK LDARSSVKAI DGEEQRAHKS
TSGEHKGSGR KDGSQYEPTN TPEDLDMDIV SVPSSVPEDI FDSLESAMEV QSSADYQGDG
NSGTEPELES SSVKLNVSSK DSRGNIKSKV TAKVRKELFV KLTPVSLSNS PIKGVDCQEV
SQEKNGRKSS GVARSSEKCR PREEISDHEN NVTILLEDSD LRRSPRVKTT PLRRQTESNP
AMSNSDEESN GTMKEKQKMS GPIRKKDKRN SADCATDNPK PHKVPKAKQP VIGDQNSDSD
EMLAVLKEAS QMGHSSSSDT DINEPQMNHK GKTGKDDNGK RKRKNSTSGS DFDTKKGKST
ETSIISKKKR QNYSESSNYD SELEREIKTM SRIGAARKSV PEKKEEDSSE DEKQGKKVVD
NGGHERAKTT QEGSSADDTG DTEGRQGGSC SIAGGSIEKV RSGVEFREML CKPGVSSDGA
EKPSVKEENV NSPEDKRVSK TKEKTKHLRS RQSRKGKGGS SDGTDRFPKK EQSDESSEGE
KKQSRQRPGT KGKKAPDLKG ETLKREQEWD SSSDGTERLP EEEEIGPFSK GIKQSKTDTA
GGEKKGKKWK DKSCEKKEEL SDSVDKLPGK GDSCDSSEDK KTRNRVSLRE KKRFSLPAKS
PGKRPECSSS DTEKSLKGQC CDSTEKRPKR IDLRERRNSS SKRNTKEVKS ASSSSDAEGS
SEDNKKQKKQ RTSAKKKTGN TKEKKRNSLR ATPKRKQVDI TSSSSDIGDD DQNSAGEESS
DEQKIKPVTE NLVLPSHTGF CQSSGDEALS KSVPATVDDD DDDNDPENRI AKKMLLEEIK
ANLSSDEDGS SDDEPDGGGK KRIGKQSEES PADDGELRRE QLAVNQVNSE SDSDSEESKK
PRYRHRLLRH KLTLSDGESG EEKPTKPKEH KEAKGRNRRK VSSEDSEDTD FQESGVSEEV
SESEDEQRPR TRSAKKAELE ENQRSYKQKK KRRRIKVQED SSSENKSHSE EDKKEGDEED
EEDEDEDEED ENDDSKSPGK GRKKIRKILK DDKLRTETQN ALKEEEERRK RIAERERERE
KLREVIEIED ASPTKCPITT KLVLDENEET KEPLVQVHRN MVIKLKPHQV DGVQFMWDCC
CESVEKTKKS PGSGCILAHC MGLGKTLQVV SFLHTVLLCD KLDFSTALVV CPLNTALNWM
NEFEKWQEGL NDNEKLEVSE LATVKRPQER SYMLQRWQED GGVMIIGYEM YRNLAQGRNV
KSRKLKDIFN KALVDPGPDF VVCDEGHILK NEASAVSKAM NSIKSRRRII LTGTPLQNNL
IEYHCMVNFI KENLLGSIKE FRNRFINPIQ NGQCADSTMV DVRVMKKRAH ILYEMLAGCV
QRKDYTALTK FLPPKHEYVL AVRMTAIQCK LYQYYLDHLT GVGNSTEGGR GKAGAKLFQD
FQMLSRIWTH PWCLQLDYIS KENKGYFDED SMDEFIASDS DETSKSLSSD EKKKPKGKKG
KKDSSSSGSG SDNDVEVIKV WNSRSRGGGD GNMDDTGNNP SVSLKLDESK TTSTSNPSSP
APDWYKDFVT DTDAEVLEHS GKMVLLFEIL RMAEEIGDKV LVFSQSLISL DLIEDFLELA
SREKTEDKEK PLIYKGEGKW IRNIDYYRLD GSTNAQSRKK WAEEFNDETN VRGRLFIIST
KAGSLGINLV AANRVIIFDA SWNPSYDIQS IFRVYRFGQT KPVYVYRFLA QGTMEDKIYD
RQVTKQSLSF RVVDQQQVER HFTMNELTEL YTFEPDLLDD PNSEKKKKRD TPMLPKDTIL
AELLQIHKEH IVGYHEHDSL LDHKEEEELT EEERKAAWAE YEAEKKGLTM RFNIPTGTNL
PPVTFTSQTP YIPFNLGALS AMSNQQLEDL INQGREKVVE ATNSMTAVRI QPLEDIISTV
WKENMNLSEA QVQALALSRQ ASQELDVKRR EAIYNDVLTK QQMLINCVQR ILMNRRLQQQ
YTQQQQQQLT YQQATLSHLM MPKPPNLIMT PSNYQQIDMR GMYQSVAGGM QPPPLQRAPP
PTVRSKNPGP SPGKSM