|
|
|
|
|
|
Description:
DNA damage-binding protein 2 (Damage-specific DNA-binding protein 2).
Molecular weight: 48375
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) pyrimidine dimer repair( GO:0006290 )
Important dates:
19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
07-FEB-2006, entry version 27.
Phylogenetic order:
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Sciurognathi Muroidea Muridae Murinae Mus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein DDB2_MOUSE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AY027937 | AAK16810.1 | - |
| Ensembl | ENSMUSG00000002109 | Mus musculus.1 | |
| MGI | MGI:1355314 | Ddb2.1 | |
| GO | GO:0006290 | P:pyrimidine dimer repair | IMP. |
| InterPro | IPR001680 | WD40. | |
| Pfam | PF00400 | WD40 | 4. |
| PRINTS | PR00320 | GPROTEINBRPT. | |
| SMART | SM00320 | WD40 | 3. |
| PROSITE | PS00678 | WD_REPEATS_1 | 1. |
| PROSITE | PS50082 | WD_REPEATS_2 | 1. |
| PROSITE | PS50294 | WD_REPEATS_REGION | 1. |
Keywords:
DNA damage; DNA repair; DNA-binding; Nuclear protein; Repeat; WD repeat.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Plasmacytoma;
RX MEDLINE=20179694; PubMed=10713455; DOI=10.1016/S0378-1119(00)00022-6;
RA Zolezzi F., Linn S.;
RT "Studies of the murine DDB1 and DDB2 genes.";
RL Gene 245:151-159(2000).
Feature:
CHAIN 1 432 DNA damage-binding protein 2.
/FTId=PRO_0000050954.
REPEAT 109 149 WD 1.
REPEAT 154 194 WD 2.
REPEAT 240 280 WD 3.
REPEAT 286 325 WD 4.
REPEAT 389 428 WD 5.
Comments:
-!- FUNCTION: Involved in the repair of UV-damaged DNA. Binds to
pyrimidine dimers.
-!- SUBUNIT: Heterodimer of DDB1 and DDB2 (By similarity).
-!- SUBCELLULAR LOCATION: Nucleus (By similarity).
-!- SIMILARITY: Contains 5 WD repeats.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Sequence length: 432
MAPKKCPETQ KSPDVAVLLR SKSRRGPQEL EPEAKKLRVQ GPVSSRTCES CCLLAELSSL
QIPSRSSSIV RDLYQHKLGK ATWSSLQQGL QKSFLHSLAS YQVFRKAAPF DRRTTSLAWH
PTHPSTLAVG SKGGDIMIWN FGIKDKPIFL KGIGAGGSIT GLKFNHLNTN QFFASSMEGT
TRLQDFKGNI LRVYTSSNSC KVWFCSLDVS AKSRVVVTGD NMGHVILLST DGKELWNLRM
HKKKVAHVAL NPCCDWLLAT ASIDQTVKIW DLRQIKGKDS FLYSLPHRHP VNAACFSPDG
ARLLTTDQNN EIRVYSASQW DSPLNLISHP HRHFQHLTPI KATWHSRHNL IVVGRYPDPN
LKSCVPYELR TIDVFDGSSG KMMCQLYDPG YSGITSLNEF NPMGDTLAST MGYHILIWSQ
EEDGSQKDHE RL