Description:
Uracil-DNA glycosylase (UDG).
Molecular weight: 33952
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
10-OCT-2003, sequence version 2.
07-FEB-2006, entry version 42.
Phylogenetic order:
Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Glires Rodentia Sciurognathi Muroidea Muridae Murinae Mus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG_MOUSE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | U55040 | AAB39511.1 | - |
| EMBL | U55041 | AAC53197.1 | - |
| EMBL | X99018 | CAA67489.1 | - |
| EMBL | Y08975 | CAA70168.1 | - |
| EMBL | BC052853 | AAH52853.1 | - |
| HSSP | P13051 | 1AKZ | |
| SMR | P97931 | 87-306.1 | |
| IntAct | P97931 | -.1 | |
| Ensembl | ENSMUSG00000029591 | Mus musculus.1 | |
| MGI | MGI:109352 | Ung.1 | |
| LinkHub | P97931 | -.1 | |
| GO | GO:0005739 | C:mitochondrion | IDA. |
| GO | GO:0005634 | C:nucleus | IDA. |
| GO | GO:0004844 | F:uracil DNA N-glycosylase activity | IDA. |
| GO | GO:0006281 | P:DNA repair | TAS. |
| InterPro | IPR003249 | U_glycsylse_notp. | |
| InterPro | IPR002043 | UDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| PANTHER | PTHR11264 | U_glycsylse_notp.1 | 1. |
| Pfam | PF03167 | UDG | 1. |
| ProDom | PD001589 | U_glycsylse_notp | 1. |
| TIGRFAMs | TIGR00628 | ung | 1. |
| PROSITE | PS00130 | U_DNA_GLYCOSYLASE | 1. |
Keywords:
Alternative splicing; DNA damage; DNA repair; Glycosidase; Hydrolase; Mitochondrion; Nuclear protein; Transit peptide.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE (ISOFORM 1).
RX MEDLINE=97311407; PubMed=9168124; DOI=10.1016/S0378-1119(96)00797-4;
RA Svendsen P.C., Yee H.A., Winkfein R.J., van de Sande J.H.;
RT "The mouse uracil-DNA glycosylase gene: isolation of cDNA and genomic
RT clones and mapping ung to mouse chromosome 5.";
RL Gene 189:175-181(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE (ISOFORMS 1 AND 2).
RX MEDLINE=97169285; PubMed=9016624; DOI=10.1093/nar/25.4.750;
RA Nilsen H., Solum K., Haug T., Krokan H.E.;
RT "Nuclear and mitochondrial uracil-DNA glycosylases are generated by
RT alternative splicing and transcription from different positions in the
RT UNG gene.";
RL Nucleic Acids Res. 25:750-755(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C3H/He; TISSUE=Osteoblast;
RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT "Generation and initial analysis of more than 15,000 full-length human
RT and mouse cDNA sequences.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
Feature:
CHAIN 1 306 Uracil-DNA glycosylase.
/FTId=PRO_0000176174.
ACT_SITE 147 147 Proton acceptor (By similarity).
VARSPLIC 1 41 MIGQKTLYSFFSPTPTGKRTTRSPEPVPGSGVAAEIGGDAV
-> MGVLGRRSLRLARRAGLRSLTPNPDSDSRQ (in
isoform 1).
/FTId=VSP_008514.
CONFLICT 277 277 Y -> H (in Ref. 1).
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine.
-!- SUBUNIT: Monomer (By similarity).
-!- SUBCELLULAR LOCATION: Mitochondrial (isoform 1). Nuclear (isoform
2).
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=2; Synonyms=UNG2;
IsoId=P97931-1; Sequence=Displayed;
Name=1; Synonyms=UNG1;
IsoId=P97931-2; Sequence=VSP_008514;
-!- PTM: Isoform 1 is processed by cleavage of a transit peptide.
-!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
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Sequence length: 306
MIGQKTLYSF FSPTPTGKRT TRSPEPVPGS GVAAEIGGDA VASPAKKARV EQNEQGSPLS
AEQLVRIQRN KAAALLRLAA RNVPAGFGES WKQQLCGEFG KPYFVKLMGF VAEERNHHKV
YPPPEQVFTW TQMCDIRDVK VVILGQDPYH GPNQAHGLCF SVQRPVPPPP SLENIFKELS
TDIDGFVHPG HGDLSGWARQ GVLLLNAVLT VRAHQANSHK ERGWEQFTDA VVSWLNQNLS
GLVFLLWGSY AQKKGSVIDR KRHHVLQTAH PSPLSVYRGF LGCRHFSKAN ELLQKSGKKP
INWKEL