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Description:
DNA mismatch repair protein mutL.
Molecular weight: 63155
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
01-MAR-2002, sequence version 1.
07-MAR-2006, entry version 21.
Phylogenetic order:
Bacteria Cyanobacteria Nostocales Nostocaceae Nostoc.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_ANASP:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000019 | BAB74754.1 | - |
| PIR | AH2187 | AH2187. | |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | BA000019_GR | alr3055.1 | |
| BioCyc | NOST-PCC-01:NOST-PCC-01-003050-MONOMER | -.1 | |
| BioCyc | NSP103690:ALR3055-MONOMER | -.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=21595285; PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S.,
RA Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T.,
RA Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A.,
RA Nakazaki N., Shimpo S., Sugimoto M., Takazawa M., Yamada M.,
RA Yasuda M., Tabata S.;
RT "Complete genomic sequence of the filamentous nitrogen-fixing
RT cyanobacterium Anabaena sp. strain PCC 7120.";
RL DNA Res. 8:205-213(2001).
Feature:
CHAIN 1 563 DNA mismatch repair protein mutL.
/FTId=PRO_0000177923.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 563
MASTIQALPQ EVVYLITAGE VIDSFAAVVR ELVENSLDAG ANRIVVYLWP QQWRVRVADN
GCGMNLDDLQ QAASAHSTSK IRSSADLWKI HSLGFRGEAL HSLTTLADVE IISRAPENVG
WRVVYGDSGK AVHVEATAIA PGTVVTVSNL FASCAARRQG LPTTAQQMKA VQATIQQIAL
CHPQTTWQVW QNDRIWFTIS PAATAGQLIP QFLPQLRPSD LQEIKLEIPN PENPQLSTNN
KPNASALALV VGLPDRCHRH RPDWVRVAIN GRMIKLPELE QTILAAFHRT LPRDRYPLCF
VHLLISPDQI NWNRNPAKTE IYLHDLSYWQ EQVTQAINQA LRISAANIPE SVQTTRVSQL
LKAAEEKGNY NFNPRNANPA DNTQNYLKAV AQVSNTYIVA EHPGGMWLVE QHIAHERVLY
EQLCDNWRLI PVEPPIILYQ LSPAQVAQLQ RIGLDIDIFG EQLWAVRNLP AMLQQREDCA
EAILELSWGG DLQTAQVAVA CRSAIRNGTP MSLPEMQKLL DDWQRTRNPR TCPHGRPIYL
SLDESSLSRF FRRHWVIGKS HGI