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Description:
Holliday junction ATP-dependent DNA helicase ruvB (EC 3.6.1.-).
Molecular weight: 40598
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
03-APR-2002, integrated into UniProtKB/Swiss-Prot.
01-MAR-2002, sequence version 1.
07-MAR-2006, entry version 27.
Phylogenetic order:
Bacteria Cyanobacteria Nostocales Nostocaceae Nostoc.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RUVB_ANASP:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000019 | BAB74593.1 | - |
| PIR | AG2167 | AG2167. | |
| HSSP | Q56214 | 1IXS | |
| GenomeReviews | BA000019_GR | all2894.1 | |
| BioCyc | NOST-PCC-01:NOST-PCC-01-002889-MONOMER | -.1 | |
| BioCyc | NSP103690:ALL2894-MONOMER | -.1 | |
| HAMAP | MF_00016 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR003959 | AAA_ATPase_centr. | |
| InterPro | IPR004605 | RuvB. | |
| InterPro | IPR008823 | RuvB_C. | |
| InterPro | IPR008824 | RuvB_N. | |
| InterPro | IPR011991 | Wing_hlx_DNA_bd. | |
| Pfam | PF00004 | AAA | 1. |
| Pfam | PF05491 | RuvB_C | 1. |
| Pfam | PF05496 | RuvB_N | 1. |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR00635 | ruvB | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; Helicase; Hydrolase; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=21595285; PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S.,
RA Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T.,
RA Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A.,
RA Nakazaki N., Shimpo S., Sugimoto M., Takazawa M., Yamada M.,
RA Yasuda M., Tabata S.;
RT "Complete genomic sequence of the filamentous nitrogen-fixing
RT cyanobacterium Anabaena sp. strain PCC 7120.";
RL DNA Res. 8:205-213(2001).
Feature:
CHAIN 1 366 Holliday junction ATP-dependent DNA
helicase ruvB.
/FTId=PRO_0000165483.
NP_BIND 88 95 ATP (Potential).
Comments:
-!- FUNCTION: The ruvA-ruvB complex in the presence of ATP renatures
cruciform structure in supercoiled DNA with palindromic sequence,
indicating that it may promote strand exchange reactions in
homologous recombination. RuvAB is an helicase that mediates the
Holliday junction migration by localized denaturation and
reannealing (By similarity).
-!- SUBUNIT: Forms a complex with ruvA (By similarity).
-!- SIMILARITY: Belongs to the ruvB family.
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Sequence length: 366
MAIISSKKQP PEPNGQPNKR PESAPSVPKE KVLQPEAAID EQGKQEESIR PQRFADYIGQ
KDLKDVLDIA IKAAKSRGEV LDHLLLYGPP GLGKTTMAMI LASEMGVNYK ITSAPALERP
RDIVGLLVNL KPGDILFIDE IHRLSRMTEE ILYPAMEDYR LDITVGKGSS ARIRSIPLSK
FTLVGATTRV GALTSPLRDR FGLIQKLRFY EVDELSQIVL RSAQLLQTQV TDDGATEIAR
RSRGTPRIAN RLLKRVRDYA QVKSCAEVSQ NIAAEALQLF QVDPCGLDWT DRRMLSVIIE
QFNGGPVGLE TIAAATGEDT QTIEEVYEPY LMQIGYLSRT PRGRTATKAA YKHMGFTPPN
EQLSLL