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Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 71697
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
01-MAR-2002, sequence version 1.
07-MAR-2006, entry version 22.
Phylogenetic order:
Bacteria Cyanobacteria Nostocales Nostocaceae Nostoc.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_ANASP:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000019 | BAB74427.1 | - |
| PIR | AI2146 | AI2146. | |
| GenomeReviews | BA000019_GR | alr2728.1 | |
| BioCyc | NOST-PCC-01:NOST-PCC-01-002723-MONOMER | -.1 | |
| BioCyc | NSP103690:ALR2728-MONOMER | -.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR000445 | HhH. | |
| InterPro | IPR003583 | HHH1_bd. | |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF00633 | HHH | 1. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| SMART | SM00278 | HhH1 | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=21595285; PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S.,
RA Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T.,
RA Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A.,
RA Nakazaki N., Shimpo S., Sugimoto M., Takazawa M., Yamada M.,
RA Yasuda M., Tabata S.;
RT "Complete genomic sequence of the filamentous nitrogen-fixing
RT cyanobacterium Anabaena sp. strain PCC 7120.";
RL DNA Res. 8:205-213(2001).
Feature:
CHAIN 1 627 UvrABC system protein C.
/FTId=PRO_0000138285.
DOMAIN 215 250 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 627
MTTSAQILPL VKDPERLEAR LSEIPPEPGV YFMRDGSDRI IYIGKSRKLR SRVRSYFREG
YNKTERIATM AKLVTEIEFI VTDTEAEALA LEANLIKQHQ PYFNVLLKDD KKYPYVCITW
SEDYPRIFIT RKRQLGKEKD KYYGPYTDSG LLREILRISK RIFALRQRPQ PLFKDRPCLN
YDLGRCPGVC QQLISPEEYR KTVQKVAMVF QGRTQELIDI LSEQMEKAAE ALNFEVAARI
RDQIAGLKSL TAEQKVSLPD DTVSRDAIAL AGDAQHACIQ LFQIRAGQLV GRLAFVAESH
AEPGAILQRV LEEHYQTAES VEIPAEILVQ HELPDAEILA DVLTQLKGRK VTIFTPQRQV
KAELIEMVER NAQYELQRMQ KLGDRNHQAT QDLAAILDLP NLPHRIEGYD ISHIQGSNAV
ASQVVFIDGL PAKQNYRHYK IKNPTVTIGH SDDFASLAEV IQRRFRKYAE DPQLSRVGNP
DWPDLIMIDG GKGQLSSVVT VLQEMNLLED LRVISLAKRR EEIFLPGESQ PLKTDAEQPG
VQLLRRLRDE AHRFAVSFHR QQRSDKLKRS RLDEIPGLGH HRQKQMLAHF RSVDYIRQAT
PSQIAEVPGI GPHLAQAIYD YFHPSHL