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Description:
UV DNA damage endonuclease (EC 3.-.-.-) (UV-endonuclease) (UVED).
Molecular weight: 37227
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 ) pyrimidine dimer repair( GO:0006290 )
Important dates:
06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
01-MAR-2002, sequence version 1.
07-MAR-2006, entry version 20.
Phylogenetic order:
Bacteria Cyanobacteria Nostocales Nostocaceae Nostoc.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVSE_ANASP:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000019 | BAB73220.1 | - |
| PIR | AD1964 | AD1964. | |
| GenomeReviews | BA000019_GR | alr1263.1 | |
| BioCyc | NOST-PCC-01:NOST-PCC-01-001261-MONOMER | -.1 | |
| BioCyc | NSP103690:ALR1263-MONOMER | -.1 | |
| HAMAP | MF_00606 | - | 1. |
| InterPro | IPR004601 | UvdE. | |
| Pfam | PF03851 | UvdE | 1. |
| TIGRFAMs | TIGR00629 | uvde | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Endonuclease; Hydrolase; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=21595285; PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S.,
RA Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T.,
RA Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A.,
RA Nakazaki N., Shimpo S., Sugimoto M., Takazawa M., Yamada M.,
RA Yasuda M., Tabata S.;
RT "Complete genomic sequence of the filamentous nitrogen-fixing
RT cyanobacterium Anabaena sp. strain PCC 7120.";
RL DNA Res. 8:205-213(2001).
Feature:
CHAIN 1 322 UV DNA damage endonuclease.
/FTId=PRO_0000215030.
Comments:
-!- FUNCTION: Component in a DNA repair pathway. Removal of UV-light
damaged nucleotides. Recognizes pyrimidine dimers and cleave a
phosphodiester bond immediately 5' to the lesion (By similarity).
-!- SIMILARITY: Belongs to the uve1/uvsE family.
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Sequence length: 322
MVTIDNSMTA TQLNDLPQTA QLRKNAQPEL GLVCITFDKK VRFRTMTRTR YLKLSLAQRE
SSLREIYLHN LQCLHDALTF CQENNLRLYR ISSALFPLSD MEDQIGSNIL EEISTDLGKI
GERSQALNIR MVLHPDQYVV LSSDSPEIVQ TSIKILERHA RTFDLLGLPR SPWSLMNIHG
GKSQRSEQLI KVISNLPENI KSRLTLENDE YAYSTEEIFN VCQKAQIPMV FDAHHQICHE
NLDSYDHPSV AAMFYAARET WTNPEWQLVH ISNGEQAFND RKHSNLITNM PNIYRQAPWI
EVEAKHKEVA IAHLRSWWLM GQ