|
|
|
|
|
|
Description:
DNA mismatch repair protein mutL.
Molecular weight: 69837
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
07-MAR-2006, entry version 22.
Phylogenetic order:
Bacteria Chlorobi Chlorobia Chlorobiales Chlorobiaceae Chlorobaculum.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_CHLTE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE006470 | AAM73245.1 | - |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | AE006470_GR | CT2028.1 | |
| TIGR | CT2028 | -. | |
| BioCyc | CTEP194439:CT2028-MONOMER | -.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TLS / ATCC 49652 / DSM 12025;
RX MEDLINE=22103685; PubMed=12093901; DOI=10.1073/pnas.132181499;
RA Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M.,
RA Dodson R.J., DeBoy R.T., Gwinn M.L., Nelson W.C., Haft D.H.,
RA Hickey E.K., Peterson J.D., Durkin A.S., Kolonay J.F., Yang F.,
RA Holt I.E., Umayam L.A., Mason T.M., Brenner M., Shea T.P.,
RA Parksey D.S., Nierman W.C., Feldblyum T.V., Hansen C.L., Craven M.B.,
RA Radune D., Vamathevan J.J., Khouri H.M., White O., Gruber T.M.,
RA Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A., Fraser C.M.;
RT "The complete genome sequence of Chlorobium tepidum TLS, a
RT photosynthetic, anaerobic, green-sulfur bacterium.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002).
Feature:
CHAIN 1 624 DNA mismatch repair protein mutL.
/FTId=PRO_0000177938.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Sequence length: 624
MASIARLPDI VANKISAGEV VQRPASVVKE LIENSIDAGA SRITVIIKDA GRQLVQIIDN
GCGMESDDVL LSVERFATSK ISEVDDLDAL RTLGFRGEAL ASISSVSHFE LKTRKAGNSL
GTLLRSDGGV IETPQPAQCE PGTSIAVRNL FFNVPARRKF LKSNATEFKH IHETVKAFVL
SYPEIEWRMM NDDEELFHFR TSDVRERLSH FYGEGFGESL IEVTEENDYM TIGGYLGKPG
MMVRQKYDQY FFINRRLIQN RMLVQAVQQA YGELLEERQS PFALLFLGLD PSLVDVNVHP
AKLEVRFEDE KSIRSMVYPV VKRAVRTADF SSEASFAAPS APTVSGEVDL PEVSSRKLSY
SSFSGKASTT GDLYRNYRAG AFSAPSSVSP MLFDSSLETS LSAGSRPTPM VQESLLTPSV
DQPDTGDGEN PVAPEKEPKI WQLHNKYIIC QIKTGLMIID QHVAHERVLY ERAIDIMNEA
APNSQQLLFP QKIDLKPWQY EVFEEISDEL YRLGFNIRPF GGMSVMIEGV PPDVRDGAEA
TILQDMIAEY QENAAKLKLE KRDNLAKSYS CRNAIMTGQK LSVEEMRMLI DRLFATRMPY
VCPHGRPVII RLSLGELDRM FGRT