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Description:
DNA mismatch repair protein mutL.
Molecular weight: 62952
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
02-MAY-2002, sequence version 2.
07-MAR-2006, entry version 34.
Phylogenetic order:
Bacteria Cyanobacteria Chroococcales Synechocystis.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_SYNY3:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000022 | BAA17380.1 | ALT_INIT |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | BA000022_GR | slr1199.1 | |
| BioCyc | SSP1148:SLR1199-MONOMER | -.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=97061201; PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T.,
RA Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S.,
RA Shimpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M.,
RA Tabata S.;
RT "Sequence analysis of the genome of the unicellular cyanobacterium
RT Synechocystis sp. strain PCC6803. II. Sequence determination of the
RT entire genome and assignment of potential protein-coding regions.";
RL DNA Res. 3:109-136(1996).
Feature:
CHAIN 1 556 DNA mismatch repair protein mutL.
/FTId=PRO_0000177983.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 556
MIQVLDRQLV DLIAAGEVID SPLAVVRELV ENALDAGADR ILVRVWWDQW RLEVLDNGQG
MDVTELKTSV LPHATSKIST QADLQRIKTL GFRGEALHSL AQVARLTISS RSVASPGCGW
RITYSPQGSP EQIEPVAIAM GTRVEVRQLF ANFPQRRQAF AKSQQFWRPM VTYLQQLALC
HPQVTWQLWQ DERLRLSLSP GPNPEAILLQ CLKSLQAGQL GYTQQSLSLP VDLENQATSA
QLSLTFGYPD RCHRPRPDWL IIAINGRPVN VPELTQTILA VFHRTLPRQR YPLCFAHWQL
PPQCIDWHRH PAKTEIYLQD LPHWQGQLKT LLHQSLAILG NDAPPRLNQL LKAAEPKGVY
QLQGASSLTE TVLGYPKAFK AIAQVCQTYV VVEHDQGIWL VEQHVAHERV LFEQLQRHWQ
CLPLEQPLVL QGFNPEQVER LQNLGLEIDP FGEDIWAVRS LPALLQGQEE IIAILRELSQ
VFSLSTAQAA IACRSAIKNG MELDRIAINK LIEQWQQCDN PHTCPHGRPI YLALDESSLA
RFFRRNWLVN PKTSGS