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Description:
ATP-dependent DNA helicase recG (EC 3.6.1.-).
Molecular weight: 93659
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
07-MAR-2006, entry version 39.
Phylogenetic order:
Bacteria Cyanobacteria Chroococcales Synechocystis.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RECG_SYNY3:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000022 | BAA10207.1 | - |
| PIR | S76355 | S76355. | |
| HSSP | Q9WY48 | 1GM5 | |
| GenomeReviews | BA000022_GR | slr0020.1 | |
| BioCyc | SSP1148:SLR0020-MONOMER | -.1 | |
| InterPro | IPR001410 | DEAD. | |
| InterPro | IPR011545 | DEAD/DEAH_N. | |
| InterPro | IPR001650 | Helicase_C. | |
| InterPro | IPR004365 | OB_tRNA_NA_bd. | |
| InterPro | IPR004609 | RecG. | |
| Pfam | PF00270 | DEAD | 1. |
| Pfam | PF00271 | Helicase_C | 1. |
| Pfam | PF01336 | tRNA_anti | 1. |
| SMART | SM00487 | DEXDc | 1. |
| SMART | SM00490 | HELICc | 1. |
| TIGRFAMs | TIGR00643 | recG | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=96127529; PubMed=8590279; DOI=10.1093/dnares/2.4.153;
RA Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N.,
RA Sugiura M., Tabata S.;
RT "Sequence analysis of the genome of the unicellular cyanobacterium
RT Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb
RT region from map positions 64% to 92% of the genome.";
RL DNA Res. 2:153-166(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=97061201; PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T.,
RA Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S.,
RA Shimpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M.,
RA Tabata S.;
RT "Sequence analysis of the genome of the unicellular cyanobacterium
RT Synechocystis sp. strain PCC6803. II. Sequence determination of the
RT entire genome and assignment of potential protein-coding regions.";
RL DNA Res. 3:109-136(1996).
Feature:
CHAIN 1 831 ATP-dependent DNA helicase recG.
/FTId=PRO_0000102159.
NP_BIND 433 440 ATP (Potential).
MOTIF 534 537 DEQH box.
Comments:
-!- FUNCTION: Critical role in recombination and DNA repair. Help
process Holliday junction intermediates to mature products by
catalyzing branch migration. Has a DNA unwinding activity
characteristic of a DNA helicase with a 3' to 5' polarity. RecG
unwind branched duplex DNA (Y-DNA) (By similarity).
-!- SIMILARITY: Belongs to the helicase family. RecG subfamily.
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Sequence length: 831
MQCSLVEVSV SVDWPRLQKA LTVEVERGFQ NLQGKQHRFG DFLCLSFGSP PPPGSSPGDR
QKWREFAQRF AQYDQLEEAE RKSLVASTRR FLHQLRRSLE SPPRDSVPKK DLLAQVNRPQ
VSEPRYPKSG QIELHTPLAT VVSQSQHQTK LLKNLGLATV EDLLFYFPRD YLDYAQQVTI
AELTAGETVT IVGRVVNCTC FTSPKNQNLN ILQIQLRDQT GRIKLSRFYA GKRFAHRGWQ
EKIKKLYPPQ AVVAASGLVK SSKFGLTLDN PEIEVLDRHS PSIDSFKVGR VLPVYPLTEG
ITADFLRKLV LACQTAIAKL SDPLPQEIRE KYELIDLQTA IAQIHFPENT EKLSLARRRL
VFDEFFYLQL GFLQRRYEQK QQQQSAIFTP HGELLEKFSD LLPFRLTQAQ QRVVNEILQD
LNKPSPMNRL VQGDVGSGKT VVGVFAILAA LQGGYQAALM APTEVLAEQH YQKLVSWFNL
LYLPVELLTG STKTAKRREI HAQLSTGQLP LLVGTHALIQ ETVNFQRLGL VVIDEQHRFG
VQQRAKLLAK GNAPHVLSMT ATPIPRTLAL TLHGDLEVSQ IDELPPGRQP IHTSVITAKE
RPQMYELIRR EVAQGRQVYI IFPAIEESEK LDIKAAVEEH KYLTEKIFPN FNIGLLHGRL
KSAEKEAALT AFREKQTEII VSTTVIEVGV DVPNATVMVI ENAERFGLSQ LHQLRGRVGR
GSHQSYCLLV TNSKSNDARQ RLGVMEQSQD GFFIAEMDLR LRGPGEFLGT KQSGLPDFAL
ASLVEDQEVL LLAREAAETM MVEDPNLEAH PDLKIKLVQR YEKLLGGEIL T