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Description:
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A).
Molecular weight: 10748
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-FEB-1997, sequence version 1.
07-MAR-2006, entry version 40.
Phylogenetic order:
Bacteria Cyanobacteria Chroococcales Synechocystis.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRA_SYNY3:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000022 | BAA17452.1 | - |
| PIR | S77349 | S77349. | |
| GenomeReviews | BA000022_GR | slr1844.1 | |
| BioCyc | SSP1148:SLR1844-MONOMER | -.1 | |
| HAMAP | MF_00205 | - | 1. |
| InterPro | IPR003439 | ABC_transp_like. | |
| InterPro | IPR004602 | UvrA_ABC. | |
| Pfam | PF00005 | ABC_tran | 1. |
| TIGRFAMs | TIGR00630 | uvra | 1. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | 2. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=97061201; PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T.,
RA Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S.,
RA Shimpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M.,
RA Tabata S.;
RT "Sequence analysis of the genome of the unicellular cyanobacterium
RT Synechocystis sp. strain PCC6803. II. Sequence determination of the
RT entire genome and assignment of potential protein-coding regions.";
RL DNA Res. 3:109-136(1996).
Feature:
CHAIN 1 970 UvrABC system protein A.
/FTId=PRO_0000093106.
DOMAIN 372 623 ABC transporter 1.
DOMAIN 634 965 ABC transporter 2.
NP_BIND 34 41 ATP (Potential).
ZN_FING 284 311 C4-type.
NP_BIND 669 676 ATP (Potential).
ZN_FING 768 794 C4-type.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrA is an ATPase and a DNA-binding
protein. A damage recognition complex composed of 2 uvrA and 2
uvrB subunits scans DNA for abnormalities. When the presence of a
lesion has been verified by uvrB, the uvrA molecules dissociate
(By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrB during the search for
lesions (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily.
-!- SIMILARITY: Contains 2 ABC transporter domains.
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Sequence length: 970
MPEQNSIRIR GARQHNLKNV NLDLPRDRLI VFTGVSGSGK SSLAFDTIFA EGQRRYVESL
SAYARQFLGQ LDKPDVDSIE GLSPAISIDQ KSTSHNPRST VGTVTEIYDY LRLLFGRAGS
PHCPHCQRNI APQTIDQMCD RVMELPDRTK FQILAPVVKG KKGTHVQLLS SLVSQGFVRV
RINGEVRELS DNIELKKNQA HTIEIVIDRL IKKEGLQERL VDSLSTCLKQ AEGTAIIDIL
DKPTLAVLDG GKKDDKEALK AAENGQAYHA ELPKEIIFSE NFACPEHGAV MDELSPRLFS
FNSPYGACPD CHGIGFVRSF CPDLVIPDPE KPVYVAIAPW SEKDNSYYLS LLYSLGQHFD
FQLQTPWKKL TKEQKEIILY GTEEEIWFEG ESRYRNKQGY YRRFAGALNI LQKNYDETNS
DAIKQKLEKY IINQPCHTCG GKRLKPEALA VKLGQYNINN LTSVPIRQTL ERIENLELTS
RQAMIGELAL KEIKARLQFL LDVGLDYLTL DRAAMTLSGG EAQRIRLATQ IGSGLTGVLY
VLDEPSIGLH QRDNNRLLAT LTKLRDLGNT LIVVEHDEDT IRHADYIVDI GPKAGIHGGE
IVCQGDFQTL LKNQRSLTGA YLSGREAIAT PEERRNGNGA KLTLQGCCHN NLRNIDVTIP
LGKLVCVTGV SGSGKSTLVN ELLHPALQHY LSRQVAFPKN LGEITGLQAI DKVIVIDQSP
IGRTPRSNPA TYTGIFDSIR EIFTQTIEAK ARGYKPGQFS FNVKGGRCEA CAGQGVNVIE
MNFLPDVYVQ CDVCKGARYN RETLQVKYKG HSIADVLAMT TEEALTVFEN IPRAVNRLQT
LVDVGLGYIK LGQPAPTLSG GEAQRVKLAS ELSRRATGKT LYLIDEPTTG LSFYDVHHLL
NVLQRLVDKG NSVLVIEHNL DVIRCSDWII DLGPEGGDRG GKIMVAGTPE TVAQHPSSYT
GKYLAKVLQS