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Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 71897
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
01-FEB-1997, sequence version 1.
07-MAR-2006, entry version 38.
Phylogenetic order:
Bacteria Cyanobacteria Chroococcales Synechocystis.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_SYNY3:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000022 | BAA17620.1 | - |
| PIR | S77286 | S77286. | |
| GenomeReviews | BA000022_GR | sll0865.1 | |
| BioCyc | SSP1148:SLL0865-MONOMER | -.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR000445 | HhH. | |
| InterPro | IPR003583 | HHH1_bd. | |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF00633 | HHH | 1. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| SMART | SM00278 | HhH1 | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=97061201; PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T.,
RA Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S.,
RA Shimpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M.,
RA Tabata S.;
RT "Sequence analysis of the genome of the unicellular cyanobacterium
RT Synechocystis sp. strain PCC6803. II. Sequence determination of the
RT entire genome and assignment of potential protein-coding regions.";
RL DNA Res. 3:109-136(1996).
Feature:
CHAIN 1 626 UvrABC system protein C.
/FTId=PRO_0000138353.
DOMAIN 215 250 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 626
MVATVSSTSL LEQPELLERR LQEIPQEPGV YFMGDRQGEI LYIGKAKKLR TRVRSYFRDS
QPHTARIALM VQQVAEIEFI VTDTEAEALA LEANLIKQHQ PHFNVLLKDD KKYPYVCITW
SETYPRIFIT RKRRLNQAKD RYYGPYVDSF SLRQTLRLIQ RIFPLRQRRQ PLFKHRPCLN
YDIGRCPGVC QELITPEDYR QTLQKVAMVF QGRTQELHQL LTQQMEKAAA DLKFEQAALI
RDQINSLGKL NADQKVSLPQ DTISRDAIAV ASDGQISAIQ LFQIRAGRLV GRLGFFADGV
ESELEKGEVL QRVLEQHYQQ VEAVEIPSEV ILPCALPDGE LLNDWLTSQR GRKVTFNLPQ
RQTKAELLEM VERNAQYELE RLQKQTAKNV TALEDLAEIL NLETLPKRIE GYDISHIQGS
NAVASQVVFI DGVPAQQYYR HYKIKNPSIK VGHSDDFASL AEVIIRRFQS SVKGKKNQQD
WPDLIMIDGG KGQLSAVVKV LKKMDLLDKF TVVSLAKQRE EIFLPGESQP LPTHAEQPGV
QLLRRLRDEA HRFAVSFHRQ QRLSKSRRSR LDEIPGLGFS RQKQLLAHFR SLDYIREASV
KQLQEVPGIG PQLAQTIYDY FHPVNS