Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 71487
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
01-JUN-2002, sequence version 1.
07-MAR-2006, entry version 19.
Phylogenetic order:
Bacteria Firmicutes Clostridia Thermoanaerobacteriales Thermoanaerobacteriaceae Thermoanaerobacter.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_THETN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE013148 | AAM25145.1 | - |
| GenomeReviews | AE008691_GR | TTE1966.1 | |
| BioCyc | TTEN119072:TTE1966-MONOMER | -.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR000445 | HhH. | |
| InterPro | IPR003583 | HHH1_bd. | |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF00633 | HHH | 2. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| SMART | SM00278 | HhH1 | 2. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MB4 / JCM 11007;
RX MEDLINE=21992816; PubMed=11997336; DOI=10.1101/gr.219302;
RA Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J.,
RA Chen Y., Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L.,
RA Tan H., Chen R., Wang J., Yu J., Yang H.;
RT "A complete sequence of the T. tengcongensis genome.";
RL Genome Res. 12:689-700(2002).
Feature:
CHAIN 1 617 UvrABC system protein C.
/FTId=PRO_0000138355.
DOMAIN 203 238 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 617
MDLQEKLKLL PEKPGVYLMK DEEGNIIYVG KASVLKNRVR QYFQNTDNHP PKVKVMLSHV
EDFEYIVTDT ELEALMLECN LIKKYKPKYN VLLKDDKNYP YIKITVAEDY PRIMFTRKID
MDGSKYFGPY GSAFAVRETI KLVRKMFPIR TCNVNIEKSL GKVRECLYYH IGLCSAPCTG
RIEKEEYRKL VDQAVMFLEG KREWLVEKLK EEMQKAADEL RFEEAARLRD QIFAIEKISE
KQKVTSINED EQDVISMARS DDIAHIEVFF VREGKLSGRE HYYMKNTEGM GREEIISSFI
KQFYESSPSV PKEIIIDVEL EEKDLLEDWL SQKRGNRVSI TVPLRGKKKE LVDMVYQNAV
EALKNEILAR EKILKDPAVL ELSNLLGIEY PKRIEAYDIS NVRGEDNVGS MVVFVDGKPK
KSEYRKFTIK YVEGQDDYQS MREMIERRFL HALEEKKQIE EGTLSKEKAK FIEMPDLILV
DGGIGHVNAA LEVIEKLGIS VPVYGMVKDS RHRTRGLVGV SGEVQMPVTG RAFRLVAQIQ
EEAHRFAITF HRERQSKRFK TDLLNIKGIG EKRAKVLYEA FGSIEEIKKA SLEELKKVKG
MNERSAKAVY EYFHGEV