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Description:
DNA mismatch repair protein mutL.
Molecular weight: 76884
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
07-FEB-2006, entry version 19.
Phylogenetic order:
Bacteria Firmicutes Bacillales Staphylococcus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_STAAU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AF378369 | AAK56306.1 | - |
| HSSP | P23367 | 1BKN | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NCTC 8325-4;
RA O'Neill A.J., Chopra I.;
RT "Mismatch repair in Staphylococcus aureus.";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
Feature:
CHAIN 1 669 DNA mismatch repair protein mutL.
/FTId=PRO_0000177973.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 669
MGKIKELQTS LANKIAAGEV VERPSSVVKE LLENAIDAGA TEISIEVEES GVQSIRVVDN
GSGIEAEDLG LVFHRHATSK LDQDEDLFHI RTLGFRGEAL ASISSVAKVT LKTCTDNANG
NEIYVENGEI LNHKPAKAKK GTDILVESLF YNTPARLKYI KSLYTELGKI TDIVNRMAMS
HPDIRIALIS DGKTMLSTNG SGRTNEVMAE IYGMKVARDL VHISGDTSDY HIEGFVAKPE
HSRSNKHYIS IFINGRYIKN FMLNKAILEG YHTLLTIGRF PICYINIEMD PILVDVNVHP
TKLEVRLSKE EQLYQLIVSK IQEAFKDRIL IPKNNLDYVP KKNKVLHSFE QQKIEFEQRQ
NTENNQEKTF SSEESNSKPF MEENRNDEIV IKEDSYNPFV TKTSESLIAD DESSGYDNTR
EKDEDYFKKQ QEILQEMDQT FDSNDGTTVQ NYENKASDDY YDVNDIKGTK SKDPKRRIPY
MEIVGQVHGT YIIAQNEFGM YMIDQHAAQE RIKYEYFRDK IGEVTNEVQD LLIPLTFHFS
KDEQLVIDQY KNELQQVGIM LEHFGGHDYI VSSYPVWFPK DEVEEIIKDM IELILEEKKV
DIKKLREDVA IMMSCKKSIK ANHYLQKHEM SDLIDQLREA EDPFTCPHGR PIIINFSKYE
LEKLFKRVM