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Description:
DNA mismatch repair protein mutS.
Molecular weight: 99904
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
01-OCT-2003, sequence version 1.
07-FEB-2006, entry version 20.
Phylogenetic order:
Bacteria Firmicutes Bacillales Staphylococcus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_STAAU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AJ296342 | CAC44463.1 | - |
| EMBL | AF378369 | AAK56305.1 | - |
| EMBL | AY324086 | AAP87081.1 | - |
| EMBL | AY324088 | AAP87083.1 | - |
| EMBL | AY324089 | AAP87084.1 | - |
| EMBL | AY324090 | AAP87085.1 | - |
| EMBL | AY324091 | AAP87086.1 | - |
| EMBL | AY324092 | AAP87087.1 | - |
| EMBL | AY324093 | AAP87088.1 | - |
| EMBL | AY324094 | AAP87089.1 | - |
| EMBL | AY324095 | AAP87090.1 | - |
| EMBL | AY324096 | AAP87091.1 | - |
| EMBL | AY324097 | AAP87092.1 | - |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NCTC 8325;
RA Schaaff F., Bierbaum G., Baumert N., Bartmann P., Sahl H.G.;
RT "A clinical S. aureus small colony variant (SCV) isolate displays a
RT mutator phenotype possible role of mutator genes in the development of
RT SCV.";
RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NCTC 8325-4;
RA O'Neill A.J., Chopra I.;
RT "Mismatch repair in Staphylococcus aureus.";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=13136p-m+, 13136p-m+V20, 13136p-m+V5, BB270V15, BB399V12,
RC BB568V15, COLV10, COLV5, HIP5827, HIP5836, and NCTC 8325 / RN450;
RA Muthaiyan A., Jayaswal R.K., Wilkinson B.J.;
RT "Intact mutS gene in laboratory-derived and clinical glycopeptide-
RT intermediate Staphylococcus aureus strains.";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
Feature:
CHAIN 1 872 DNA mismatch repair protein mutS.
/FTId=PRO_0000115141.
NP_BIND 602 609 ATP (Potential).
VARIANT 706 706 T -> P (in strain: BB399V12).
VARIANT 840 840 E -> K (in strain: BB270V15, NCTC 8325-4
and RN450).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 872
MSNVTPMMQQ YLKIKSEYQD CLLFFRLGDF YEMFYEDAKE ASRVLEITLT KRDAKKENPI
PMCGVPYHSA DSYIDTLVNN GYKVAICEQM EDPKQTKGMV RREVVRIVTP GTVMEQGGVD
DKQNNYILSF VMNQPEIALS YCDVSTGELK VTHFNDEATL LNEITTINPN EVVINDNISD
NLKRQINMVT ETITVRETLS SEIYSVNQTE HKLMYQATQL LLDYIHHTQK RDLSHIEDVV
QYAAIDYMKM DFYAKRNLEL TESIRLKSKK GTLLWLMDET KTPMGARRLK QWIDRPLISK
EQIEARLDIV DEFSAHFIER DTLRTYLNQV YDIERLVGRV SYGNVNARDL IQLKHSISEI
PNIKALLNSM NQNTLVQVNQ LEPLDDLLDI LEQSLVEEPP ISVKDGGLFK VGFNTQLDEY
LEASKNGKTW LAELQAKERQ RTGIKSLKIS FNKVFGYFIE ITRANLQNFE PSEFGYMRKQ
TLSNAERFIT DELKEKEDII LGAEDKAIEL EYQLFVQLRE EVKKYTERLQ QQAKIISELD
CLQSFAEIAQ KYNYTRPSFS ENKTLELVES RHPVVERVMD YNDYVPNNCR LDNETFIYLI
TGPNMSGKST YMRQVAIISI MAQMGAYVPC KEAVLPIFDQ IFTRIGAADD LVSGKSTFMV
EMLEAQKALT YATEDSLIIF DEIGRGTSTY DGLALAQAMI EYVAETSHAK TLFSTHYHEL
TTLDQALPSL KNVHVAANEY KGELIFLHKV KDGAVDDSYG IQVAKLADLP EKVISRAQVI
LSEFEASAGK KSSISNLKMV ENEPEINQEN LNLSVEETTD TLSQKDFEQA SFDLFENDQE
SEIELQIKNL NLSNMTPIEA LVKLSELQNQ LK