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Description:
Protein recA (Recombinase A).
Molecular weight: 37657
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
21-DEC-2004, sequence version 1.
07-MAR-2006, entry version 10.
Phylogenetic order:
Bacteria Firmicutes Bacillales Staphylococcus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RECA_STAAU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | L25893 | AAA50463.1 | - |
| EMBL | AF317802 | AAK15276.1 | - |
| EMBL | M94061 | AAA26667.1 | - |
| PIR | F42721 | F42721. | |
| HSSP | Q59560 | 1UBC | |
| HAMAP | MF_00268 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR001553 | RecA_bac. | |
| Pfam | PF00154 | RecA | 1. |
| PRINTS | PR00142 | RECA. | |
| ProDom | PD000229 | RecA | 1. |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR02012 | tigrfam_recA | 1. |
| PROSITE | PS00321 | RECA_1 | 1. |
| PROSITE | PS50162 | RECA_2 | 1. |
| PROSITE | PS50163 | RECA_3 | 1. |
Keywords:
ATP-binding; DNA damage; DNA recombination; DNA repair; DNA-binding; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX MEDLINE=94374696; PubMed=8088537; DOI=10.1016/0378-1119(94)90033-7;
RA Bayles K.W., Brunskill E.W., Iandolo J.J., Hruska L.L., Huang S.,
RA Pattee P.A., Smiley B.K., Yasbin R.E.;
RT "A genetic and molecular characterization of the recA gene from
RT Staphylococcus aureus.";
RL Gene 147:13-20(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Bisognano C., Kelley W.L., Francois P., Lew D.P., Hooper D.C.,
RA Vaudaux P.;
RT "Insertional inactivation of recA, but not agr or sar, abolishes
RT increased adhesion to fibronectin evoked by sub-inhibitory levels of
RT ciprofloxacin in quinolone resistant Staphylococcus aureus.";
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 101-204.
RC STRAIN=ILRN450;
RX MEDLINE=92332463; PubMed=1629178;
RA Duwat P., Ehrlich S.D., Gruss A.;
RT "A general method for cloning recA genes of Gram-positive bacteria by
RT polymerase chain reaction.";
RL J. Bacteriol. 174:5171-5175(1992).
Feature:
CHAIN 1 347 Protein recA.
/FTId=PRO_0000122843.
NP_BIND 65 72 ATP (By similarity).
Comments:
-!- FUNCTION: Can catalyze the hydrolysis of ATP in the presence of
single-stranded DNA, the ATP-dependent uptake of single-stranded
DNA by duplex DNA, and the ATP-dependent hybridization of
homologous single-stranded DNAs. It interacts with lexA causing
its activation and leading to its autocatalytic cleavage.
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the recA family.
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Sequence length: 347
MDNDRQKALD TVIKNMEKSF GKGAVMKLGD NIGRRVSTTS TGSVTLDNAL GVGGYPKGRI
IEIYGPESSG KTTVALHAIA EVQSNGGVAA FIDAEHALDP EYAQALGVDI DNLYLSQPDH
GEQGLEIAEA FVRSGAVDIV VVDSVAALTP KAEIEGEMGD THVGLQARLM SQALRKLSGA
ISKSNTTAIF INQIREKVGV MFGNPETTPG GRALKFYSSV RLEVRRAEQL KQGQEIVGNR
TKIKVVKNKV APPFRVAEVD IMYGQGISKE GELIDLGVEN DIVDKSGAWY SYNGERMGQG
KENVKMYLKE NPQIKEEIDR KLREKLGISD GDVEETEDAP KSLFDEE