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Description:
ATP-dependent DNA helicase recG (EC 3.6.1.-).
Molecular weight: 78343
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-JUN-1998, sequence version 1.
07-FEB-2006, entry version 30.
Phylogenetic order:
Bacteria Firmicutes Bacillales Staphylococcus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RECG_STAAU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AB000439 | BAA24572.1 | - |
| HSSP | Q9WY48 | 1GM5 | |
| InterPro | IPR001410 | DEAD. | |
| InterPro | IPR011545 | DEAD/DEAH_N. | |
| InterPro | IPR001650 | Helicase_C. | |
| InterPro | IPR004365 | OB_tRNA_NA_bd. | |
| InterPro | IPR004609 | RecG. | |
| InterPro | IPR004589 | RecQ. | |
| PANTHER | PTHR13710 | RecQ.1 | 1. |
| Pfam | PF00270 | DEAD | 1. |
| Pfam | PF00271 | Helicase_C | 1. |
| Pfam | PF01336 | tRNA_anti | 1. |
| SMART | SM00487 | DEXDc | 1. |
| SMART | SM00490 | HELICc | 1. |
| TIGRFAMs | TIGR00643 | recG | 1. |
Keywords:
ATP-binding; DNA damage; DNA recombination; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NCTC 8325 / RN4220;
RX MEDLINE=97400264; PubMed=9257758;
RA Niga T., Yoshida H., Hattori H., Nakamura S.;
RT "Cloning and sequencing of a novel gene (recG) that affects the
RT quinolone susceptibility of Staphylococcus aureus.";
RL Antimicrob. Agents Chemother. 41:1770-1774(1997).
Feature:
CHAIN 1 686 ATP-dependent DNA helicase recG.
/FTId=PRO_0000102152.
NP_BIND 292 299 ATP (Potential).
MOTIF 392 395 DEQH box.
Comments:
-!- FUNCTION: Critical role in recombination and DNA repair. Help
process Holliday junction intermediates to mature products by
catalyzing branch migration. Has a DNA unwinding activity
characteristic of a DNA helicase with a 3' to 5' polarity. RecG
unwind branched duplex DNA (Y-DNA) (By similarity).
-!- SIMILARITY: Belongs to the helicase family. RecG subfamily.
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Sequence length: 686
MAKVNLIESP YSLLQLKGIG PKKIEVLQQL NIHTVEDLVL YLPTRYEDNT VIDLNQAEDQ
SNVTIEGQVY TAPVVAFFGR NKSKLTVHLM VNNIAVKCIF FNQPYLKKKI ELNQTITVKG
KWNRVKQEIT GNRVFFNSQG TQTQENADVQ LEPVYRIKEG IKQKQIRDQI RQALNDVTIH
EWLTDELREK YKLETLDFTL NTLHHPKSKE DLLRARRTYA FTELFLFELR MQWLNRLEKS
SDEAIEIDYD IDQVKSFIDR LPFELTEAQK SSVNEIFRDL KAPIRMHRLL QGDVGSGKTV
VAAICMYALK TAGYQSALMV PTEILAEQHA ESLMALFGDS MNVALLTGSV KGKKRKILLE
QLENGTIDCL IGTHALIQDD VIFHNVGLVI TDEQHRFGVN QRQLLREKGA MTNVLFMTAT
PIPRTLAISV FGEMDVSSIK QLPKGRKPII TTWAKHEQYD KVLMQMTSEL KKGRQAYVIC
PLIESSEHLE DVQNVVALYE SLQQYYGVSR VGLLHGKLSA DEKDEVMQKF SNHEINVLVS
TTVVEVGVNV PNATFMMIYD ADRFGLSTLH QLRGRVGRSD QQSYCVLIAS PKTETGIERM
TIMTQTTDGF ELSERDLEMR GPGDFFGVKQ SGLPDFLVAN LVEDYRMLEV ARDEAAELIQ
SGVFFENTYQ HLRHFVEENL LHRSFD