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Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 68644
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
07-MAR-2006, entry version 32.
Phylogenetic order:
Bacteria Firmicutes Bacillales Staphylococcus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_STAAU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AJ223480 | CAA11405.1 | - |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Oxford;
RA Uziel O., Borovok I., Schreiber R., Cohen G., Aharonowitz Y.;
RT "Transcriptional analysis of the thioredoxin (trxA) and thioredoxin
RT reductase (trxB) genes in Staphylococcus aureus.";
RL Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
Feature:
CHAIN 1 593 UvrABC system protein C.
/FTId=PRO_0000138341.
DOMAIN 199 234 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 593
MEDYKKRIKN KLNVVPMEPG CYLMKDRNDQ VIYVGKAKKL RNRLRSYFTG AHDAKTTRLV
GEIRRFEFIV TSSETESLLL ELNLIKQYQP RYNILLKDDK SYPFIKITKE KYPRLLVTRT
VKQGTGKYFG PYPNAYSAQE TKKLLDRIYP YRKCDKMPDK LCLYYHIGQC LGPCVYDVDL
SKYAQMTKEI TDFLNGEDKT ILKSLEERML TASESLDFER AKEYRDLIQH IQNLTNKQKI
MSSDKTIRDV FGYSVDKGWM CIQVFFIRQG NMIKRDTTMI PLQQTEEEEF YTFIGQFYSL
NQHILPKEVH VPRNLDKEMI QSVVDTKIVQ PARGPKKDMV DLAAHNAKVS LNNKFELISR
DESRTIKAIE ELGTQMGIQT PIRIEAFDNS NIQGVDPVSA MVTFVDGKPD KKNYRKYKIK
TVKGPDDYKS MREVVRRRYS RVLNEGLPLP DLIIVDGGKG HMNGVIDVLQ NELGLDIPVA
GLQKNDKHQT SELLYGASAE IVPLKKNSQA FYLLHRIQDE VHRFAITFHR QTRQKTGLKS
ILDDIDGIGS KRKTLLLRSF GSIKKMKEAT LEDFKNIGIP ENVAKNLHEQ LHK