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Description:
DNA mismatch repair protein mutL.
Molecular weight: 57945
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
07-MAR-2006, entry version 29.
Phylogenetic order:
Bacteria Deinococcus-Thermus Deinococci Deinococcales Deinococcaceae Deinococcus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_DEIRA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000513 | AAF11253.1 | - |
| PIR | G75364 | G75364. | |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | AE000513_GR | DR1696.1 | |
| TIGR | DR1696 | -. | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R1 / ATCC 13939 / DSM 20539 / NCIB 9279;
RX MEDLINE=20036896; PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA Fraser C.M.;
RT "Genome sequence of the radioresistant bacterium Deinococcus
RT radiodurans R1.";
RL Science 286:1571-1577(1999).
Feature:
CHAIN 1 547 DNA mismatch repair protein mutL.
/FTId=PRO_0000177942.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 547
MPTPIHVLPP HVARLIAAGE VVSRPLDVVR ELVENALDAG ASRIEIEVDG GGLERVQVRD
NGSGIAAQSV PLAPARHATS KLTAGPETGS LSVTTLGFRG EALWAAAQAG ELELTTRPAA
QVGAARLRAQ GDAVEVSRTS APAGTTVTVS QLFARLPARL RTQASAAAEV RDITALLGRY
VLHHSALHWR LTVDGDPRLT HAPADHRGAV ATVYGPLSAN RVLTLDTPGV RGVVSRPELT
RARRDRMHFA VNGRPIVAPP ELERAVIDAY AELLPAGTAP LCVLDLTVAP EDYDPNIHPA
KQVVALADLP AVALRVRDAV AGALAGHPLV RAAPALIAPP EPHPAPTAGN FPDLTLLGVY
QELYLLAQGE GDLWVVDAHA AHERALYERL GRELGTAAPL ELPTPELLHL TPEQTARLHE
RGAELRGWGL TIEDFGAGLA RLRTLPAALA ALPVPRLHEV VVETALSGGP DPRREVLARL
ACLPALKAGM LDAERGALVL AALRECEQPW ACPHGRPTVL RLSERDLAHA FGRRGVRDVA
RGRDSVV