|
|
|
|
|
|
Description:
Protein recA (Recombinase A).
Molecular weight: 38145
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
30-MAY-2000, sequence version 2.
07-MAR-2006, entry version 48.
Phylogenetic order:
Bacteria Deinococcus-Thermus Deinococci Deinococcales Deinococcaceae Deinococcus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RECA_DEIRA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | U01876 | AAC33148.1 | - |
| EMBL | AB005471 | BAA21330.1 | - |
| EMBL | AE000513 | AAF11887.1 | - |
| PIR | C75285 | C75285. | |
| PDB | 1XP8 | X-ray | A=1-363. |
| GenomeReviews | AE000513_GR | DR2340.1 | |
| TIGR | DR2340 | -. | |
| HAMAP | MF_00268 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR001553 | RecA_bac. | |
| Pfam | PF00154 | RecA | 1. |
| PRINTS | PR00142 | RECA. | |
| ProDom | PD000229 | RecA | 1. |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR02012 | tigrfam_recA | 1. |
| PROSITE | PS00321 | RECA_1 | 1. |
| PROSITE | PS50162 | RECA_2 | 1. |
| PROSITE | PS50163 | RECA_3 | 1. |
Keywords:
3D-structure; ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=R1 / ATCC 13939 / DSM 20539 / NCIB 9279;
RX MEDLINE=94215885; PubMed=8163172; DOI=10.1016/0378-1119(94)90124-4;
RA Gutman P.D., Carroll J.D., Masters C.I., Minton K.W.;
RT "Sequencing, targeted mutagenesis and expression of a recA gene
RT required for the extreme radioresistance of Deinococcus radiodurans.";
RL Gene 141:31-37(1994).
RN [2]
RP SEQUENCE REVISION.
RA Carroll J.D.;
RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND MUTANT REC30.
RC STRAIN=KD8301;
RX MEDLINE=20075120; PubMed=10606814; DOI=10.1016/S0921-8777(99)00048-8;
RA Narumi I., Satoh K., Kikuchi M., Funayama T., Kitayama S.,
RA Yanagisawa T., Watanabe H., Yamamoto K.;
RT "Molecular analysis of the Deinococcus radiodurans recA locus and
RT identification of a mutation site in a DNA repair-deficient mutant,
RT rec30.";
RL Mutat. Res. 435:233-243(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R1 / ATCC 13939 / DSM 20539 / NCIB 9279;
RX MEDLINE=20036896; PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA Fraser C.M.;
RT "Genome sequence of the radioresistant bacterium Deinococcus
RT radiodurans R1.";
RL Science 286:1571-1577(1999).
Feature:
CHAIN 1 363 Protein recA.
/FTId=PRO_0000122700.
NP_BIND 78 85 ATP (By similarity).
VARIANT 224 224 G -> S (in rec30; DNA-repair deficient).
HELIX 17 33
TURN 35 36
STRAND 37 38
TURN 41 42
STRAND 43 43
STRAND 51 52
STRAND 55 55
HELIX 57 62
TURN 63 63
STRAND 64 69
TURN 70 71
STRAND 72 79
TURN 80 81
STRAND 82 83
HELIX 84 97
TURN 98 99
STRAND 102 108
HELIX 113 118
TURN 119 120
HELIX 123 125
STRAND 127 129
STRAND 132 133
HELIX 134 145
TURN 146 148
STRAND 151 156
TURN 158 160
STRAND 164 164
TURN 165 166
HELIX 178 194
TURN 195 197
STRAND 200 206
HELIX 224 230
STRAND 232 241
STRAND 252 265
STRAND 270 276
TURN 277 279
STRAND 280 281
HELIX 283 293
TURN 294 295
STRAND 296 300
TURN 301 302
STRAND 303 314
HELIX 315 322
TURN 323 324
HELIX 326 340
Comments:
-!- FUNCTION: Can catalyze the hydrolysis of ATP in the presence of
single-stranded DNA, the ATP-dependent uptake of single-stranded
DNA by duplex DNA, and the ATP-dependent hybridization of
homologous single-stranded DNAs. It interacts with lexA causing
its activation and leading to its autocatalytic cleavage.
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the recA family.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Sequence length: 363
MSKDATKEIS APTDAKERSK AIETAMSQIE KAFGKGSIMK LGAESKLDVQ VVSTGSLSLD
LALGVGGIPR GRITEIYGPE SGGKTTLALA IVAQAQKAGG TCAFIDAEHA LDPVYARALG
VNTDELLVSQ PDNGEQALEI MELLVRSGAI DVVVVDSVAA LTPRAEIEGD MGDSLPGLQA
RLMSQALRKL TAILSKTGTA AIFINQVREK IGVMYGNPET TTGGRALKFY ASVRLDVRKI
GQPTKVGNDA VANTVKIKTV KNKVAAPFKE VELALVYGKG FDQLSDLVGL AADMDIIKKA
GSFYSYGDER IGQGKEKTIA YIAERPEMEQ EIRDRVMAAI RAGNAGEAPA LAPAPAAPEA
AEA