|
|
|
|
|
|
Description:
Uracil-DNA glycosylase (EC 3.2.2.-) (UDG).
Molecular weight: 27746
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
07-MAR-2006, entry version 32.
Phylogenetic order:
Bacteria Deinococcus-Thermus Deinococci Deinococcales Deinococcaceae Deinococcus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG_DEIRA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000513 | AAF10269.1 | - |
| PIR | F75486 | F75486. | |
| PDB | 2BOO | X-ray | A=1-247. |
| GenomeReviews | AE000513_GR | DR0689.1 | |
| TIGR | DR0689 | -. | |
| HAMAP | MF_00148 | - | 1. |
| InterPro | IPR003249 | U_glycsylse_notp. | |
| InterPro | IPR002043 | UDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| PANTHER | PTHR11264 | U_glycsylse_notp.1 | 1. |
| Pfam | PF03167 | UDG | 1. |
| ProDom | PD001589 | U_glycsylse_notp | 1. |
| TIGRFAMs | TIGR00628 | ung | 1. |
| PROSITE | PS00130 | U_DNA_GLYCOSYLASE | 1. |
Keywords:
3D-structure; Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R1 / ATCC 13939 / DSM 20539 / NCIB 9279;
RX MEDLINE=20036896; PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA Fraser C.M.;
RT "Genome sequence of the radioresistant bacterium Deinococcus
RT radiodurans R1.";
RL Science 286:1571-1577(1999).
Feature:
CHAIN 1 247 Uracil-DNA glycosylase.
/FTId=PRO_0000176090.
ACT_SITE 83 83 Proton acceptor (By similarity).
STRAND 19 19
TURN 21 22
HELIX 25 35
TURN 36 36
STRAND 37 37
HELIX 38 53
STRAND 54 54
STRAND 56 58
HELIX 60 62
TURN 63 64
HELIX 65 69
STRAND 70 70
HELIX 72 74
STRAND 77 83
STRAND 87 87
TURN 88 89
STRAND 92 96
TURN 100 101
STRAND 102 102
HELIX 106 118
STRAND 119 119
TURN 120 121
STRAND 126 127
HELIX 131 134
TURN 135 137
STRAND 138 144
STRAND 147 148
TURN 149 150
STRAND 151 151
TURN 152 157
STRAND 158 159
HELIX 160 172
TURN 173 173
STRAND 175 176
STRAND 179 184
HELIX 185 193
TURN 197 198
STRAND 200 204
STRAND 207 208
TURN 209 211
HELIX 212 214
TURN 215 217
HELIX 220 230
TURN 231 232
STRAND 242 243
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Sequence length: 247
MTDQPDLFGL APDAPRPIIP ANLPEDWQEA LLPEFSAPYF HELTDFLRQE RKEYTIYPPA
PDVFNALRYT PLGEVKVLIL GQDPYHGPNQ AHGLSFSVRP GVRVPPSLRN IYKELTEDIP
GFVAPKHGYL RSWAEQGVLL LNAVLTVRAG QANSHQGKGW EHFTDAVIKA VNAKEERVVF
ILWGSYARKK KKLITGKNHV VIESGHPSPL SEQYFFGTRP FSKTNEALEK AGRGPVEWQL
PATVTEE