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Description:
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A).
Molecular weight: 1121
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
30-MAY-2000, sequence version 2.
07-MAR-2006, entry version 46.
Phylogenetic order:
Bacteria Deinococcus-Thermus Deinococci Deinococcales Deinococcaceae Deinococcus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRA_DEIRA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | U52145 | AAC44646.1 | - |
| EMBL | AB001610 | BAA21368.1 | - |
| EMBL | AE000513 | AAF11324.1 | - |
| PIR | H75356 | H75356. | |
| GenomeReviews | AE000513_GR | DR1771.1 | |
| TIGR | DR1771 | -. | |
| HAMAP | MF_00205 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR003439 | ABC_transp_like. | |
| InterPro | IPR004602 | UvrA_ABC. | |
| Pfam | PF00005 | ABC_tran | 2. |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR00630 | uvra | 1. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | 2. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=R1 / ATCC 13939 / DSM 20539 / NCIB 9279;
RX MEDLINE=97113433; PubMed=8955293;
RA Agostini H.J., Carroll J.D., Minton K.W.;
RT "Identification and characterization of uvrA, a DNA repair gene of
RT Deinococcus radiodurans.";
RL J. Bacteriol. 178:6759-6765(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KD8301;
RX MEDLINE=98036039; PubMed=9370272; DOI=10.1016/S0378-1119(97)00301-6;
RA Narumi I., Cherdchu K., Kitayama S., Watanabe H.;
RT "The Deinococcus radiodurans uvr A gene: identification of mutation
RT sites in two mitomycin-sensitive strains and the first discovery of
RT insertion sequence element from deinobacteria.";
RL Gene 198:115-126(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R1 / ATCC 13939 / DSM 20539 / NCIB 9279;
RX MEDLINE=20036896; PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA Fraser C.M.;
RT "Genome sequence of the radioresistant bacterium Deinococcus
RT radiodurans R1.";
RL Science 286:1571-1577(1999).
Feature:
CHAIN 1 1016 UvrABC system protein A.
/FTId=PRO_0000093048.
DOMAIN 403 633 ABC transporter 1.
DOMAIN 644 975 ABC transporter 2.
NP_BIND 32 39 ATP (Potential).
ZN_FING 259 286 C4-type.
NP_BIND 679 686 ATP (Potential).
ZN_FING 778 804 C4-type.
CONFLICT 282 282 A -> P (in Ref. 1).
CONFLICT 395 397 DTE -> TP (in Ref. 1).
CONFLICT 470 470 R -> A (in Ref. 1).
CONFLICT 677 677 V -> E (in Ref. 1).
CONFLICT 682 682 G -> R (in Ref. 1).
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrA is an ATPase and a DNA-binding
protein. A damage recognition complex composed of 2 uvrA and 2
uvrB subunits scans DNA for abnormalities. When the presence of a
lesion has been verified by uvrB, the uvrA molecules dissociate
(By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrB during the search for
lesions (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily.
-!- SIMILARITY: Contains 2 ABC transporter domains.
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Sequence length: 1016
MQDKLIVRGA REHNLKDITV ELPRDRFVVI TGVSGSGKST LAFDTIYAEG QRRYVESLSA
YARQFLGLME KPDVDSITGL SPAISIDQKT TSHNPRSTVG TVTEIHDYLR LLYARVGTPY
CPICGRKIEK QSPSEVTDRL LAGFPDKRAI LLAPAVRGRK GEYKKLFADL RREGYARVRV
DGTLYELEEA EKLKLEKFEK HDVDIVIDRL TLRESDRSRI AESVELGIRR GEGLLRVLLP
DAGEDGGAHE ELYSEKFACP EHGSVLEELE PRSFSFNSPY GACGDCAGIG AKQEFSPERI
IDEKLSIAGG AIIPWTKKGA DAGIYYWDKL KALAEHLDFD LKTPWKDLPA KAQKAVLHGP
GEAFEVVYRR GGKETMRFMT EFEGVITNLE RRYADTESEF MRERLEELME LRPCPTCGGT
RYKPEILAVR VGGLNISQTS GMSVLDADAF FQQLQEGELD HAAIEPFLKR HTGGTAKAHG
PLHYEYDLGT FGAAVAAPIL RAIRTRLKFL VDVGLDYLSL DRTANTLSGG EAQRIRLATQ
VGSGLTGVLY VLDEPSIGLH PKDNGRLIGT LKNLRDLGNS LLVVEHDEDT MLEADYLIDM
GPGAGVHGGE VIASGTPEQV KQDKNSLTGK YLRGEMKIEV PAERRPGNGK FLKVFGARQN
NLQDVDVSIP LGTMTVVTGP SGSGKSTLIH DILHATLARE LNGAKTTPGL YDRIEGMEQL
DKVIEIDQSP IGRTPRSNPA TYTGVFTEIR DLFTRTPEAR RRGYQAGRFS FNVKGGRCEH
CKGDGVMKIE MNFLPDIYVP CEVCHGARYN RETLEVKYNH KTIADVLDLT VEDAHEFFEA
IPTIERKMQL LLDVGLGYMK IGQPSTTLSG GEAQRIKLAT ELSKRATGRT IYILDEPTTG
LHFEDVRKLM DVLQRLAEGG NTLVIIEHNL DVMKSADYLI DLGPEGGVRG GTVVAVGTPE
EVAAHPTSYT GEYLRKVPGI VAAEPRARGE KAEKPAKAKA PAKKRTKKQT ELVEAD