Description:
Uracil-DNA glycosylase (EC 3.2.2.-) (UDG).
Molecular weight: 24050
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
26-SEP-2001, sequence version 2.
07-MAR-2006, entry version 51.
Phylogenetic order:
Bacteria Firmicutes Lactobacillales Streptococcaceae Streptococcus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG_STRPN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | X55651 | CAA39182.1 | - |
| EMBL | Z21702 | CAA79806.1 | - |
| EMBL | AE007417 | AAK75278.1 | - |
| PIR | E95135 | E95135. | |
| PIR | S13591 | S13591. | |
| HSSP | P13051 | 1AKZ | |
| GenomeReviews | AE005672_GR | SP1169.1 | |
| TIGR | SP1169 | -. | |
| BioCyc | SPNE170187:SP1169-MONOMER | -.1 | |
| HAMAP | MF_00148 | - | 1. |
| InterPro | IPR003249 | U_glycsylse_notp. | |
| InterPro | IPR002043 | UDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| PANTHER | PTHR11264 | U_glycsylse_notp.1 | 1. |
| Pfam | PF03167 | UDG | 1. |
| ProDom | PD001589 | U_glycsylse_notp | 1. |
| TIGRFAMs | TIGR00628 | ung | 1. |
| PROSITE | PS00130 | U_DNA_GLYCOSYLASE | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=R800;
RX MEDLINE=91067468; PubMed=2251133;
RA Mejean V., Rives I., Claverys J.-P.;
RT "Nucleotide sequence of the Streptococcus pneumoniae ung gene encoding
RT uracil-DNA glycosylase.";
RL Nucleic Acids Res. 18:6693-6693(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-334 / TIGR4;
RX MEDLINE=21357209; PubMed=11463916; DOI=10.1126/science.1061217;
RA Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T.,
RA Hickey E.K., Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C.,
RA Dougherty B.A., Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT "Complete genome sequence of a virulent isolate of Streptococcus
RT pneumoniae.";
RL Science 293:498-506(2001).
Feature:
CHAIN 1 217 Uracil-DNA glycosylase.
/FTId=PRO_0000176152.
ACT_SITE 62 62 Proton acceptor (By similarity).
CONFLICT 203 203 A -> T (in Ref. 1).
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine.
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
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Sequence length: 217
MEHSSWHALI KAQLPEGYFG KINQFMEQVY SQGIIYPPKE KVFQALLTTL LEEVKVVILG
QDPYHGPGQA QGLSFSVPDS IPAPPSLQNI LKELSDDIGV KKSHDLTAWA EQGVLLLNAC
LTVPAGQANG HAGQIWEPFT DAVIQVVNHL DRPVVFVLWG AYARKKKALV TNPHHLIIES
AHPSPLSVYR GFWGSKPFSK ANAFLKETGQ EPIDWLR