Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 68026
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
28-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
07-MAR-2006, entry version 20.
Phylogenetic order:
Bacteria Firmicutes Mollicutes Mycoplasmataceae Ureaplasma.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_UREPA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE002135 | AAF30791.1 | - |
| GenomeReviews | AF222894_GR | UU381.1 | |
| BioCyc | UURE2130:UU381-MONOMER | -.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700970 / Serovar 3;
RX MEDLINE=20500219; PubMed=11048724; DOI=10.1038/35037619;
RA Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y.,
RA Cassell G.H.;
RT "The complete sequence of the mucosal pathogen Ureaplasma
RT urealyticum.";
RL Nature 407:757-762(2000).
Feature:
CHAIN 1 584 UvrABC system protein C.
/FTId=PRO_0000138357.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Sequence length: 584
MNDLLKNKLK LIPHKPGCYL WKDQFNQIIY IGKAKDLYNR THSYFNGCKD NKTSKLVNNI
NDLEYIVVNN VNEALILENN LIKTHLPKYN ILLKDGSNYP YIMITNEQYP RLKYVRTYDK
NKGIYFGPLA DSTNKYQLFN LLNSIFPFNK CNHQPYKKCI YYDLHQCINQ VQQSTYQEAI
SEVKEIFKGN LDHILMILQT KEQHAVTKLD FENAQKYAEQ QKALTSIINS GLVQLDNNES
FDIIGFYEKN NYLVIIIFNY VKGKLLNKSA DTFAIYDYEI NELITSFLMQ YYSQNKISSK
IIVSLDDDNL LALSQRFHTK FINAQTKFHK RILKLALDNA ILYFESNIKN VINKQNELDD
ALNQLKQILK LPDLNIIECF DNSNINLSLP IAGMIVYQNG KLNNKLNRKY NLMTTKNASD
YHFMIEVITR RYQRLVSQHQ KLPNLIVVDG GKLQVNAALY ALAQLQINIP LIGLKKDQKH
KTDAIVLTNG DEIVLDRKSI LYKFLANMQN DVHNYAISFL RDKHTKSIFN SLLDNVQGLG
KKRFNELLKY YDSINDLKSA SDQELLQFLP KNVLVNLREK LNKI