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Description:
ATP-dependent Clp protease ATP-binding subunit clpE.
Molecular weight: 83145
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
07-MAR-2006, entry version 30.
Phylogenetic order:
Bacteria Firmicutes Lactobacillales Streptococcaceae Lactococcus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein CLPE_LACLA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE006289 | AAK04655.1 | - |
| PIR | E86694 | E86694. | |
| HSSP | P03815 | 1JBK | |
| GenomeReviews | AE005176_GR | LL0557.1 | |
| BioCyc | LLAC1360:L0221-MONOMER | -.1 | |
| InterPro | IPR013093 | AAA_2. | |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR003959 | AAA_ATPase_centr. | |
| InterPro | IPR001270 | Chaprnin_clpA/B. | |
| InterPro | IPR001943 | UvrB/C. | |
| Pfam | PF00004 | AAA | 1. |
| Pfam | PF07724 | AAA_2 | 1. |
| Pfam | PF02151 | UVR | 1. |
| PRINTS | PR00300 | CLPPROTEASEA. | |
| SMART | SM00382 | AAA | 2. |
| PROSITE | PS00870 | CLPAB_1 | 1. |
| PROSITE | PS00871 | CLPAB_2 | 1. |
| PROSITE | PS50151 | UVR | 1. |
Keywords:
ATP-binding; Chaperone; Complete proteome; Heat shock; Metal-binding; Nucleotide-binding; Repeat; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL1403;
RX MEDLINE=21235186; PubMed=11337471; DOI=10.1101/gr.169701;
RA Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K.,
RA Weissenbach J., Ehrlich S.D., Sorokin A.;
RT "The complete genome sequence of the lactic acid bacterium Lactococcus
RT lactis ssp. lactis IL1403.";
RL Genome Res. 11:731-753(2001).
Feature:
CHAIN 1 748 ATP-dependent Clp protease ATP-binding
subunit clpE.
/FTId=PRO_0000191225.
DOMAIN 359 394 UVR.
ZN_FING 3 32 C4-type (Potential).
NP_BIND 152 159 ATP (Potential).
NP_BIND 481 488 ATP (Potential).
REGION 107 354 I.
REGION 407 598 II.
Comments:
-!- FUNCTION: Could be necessary for degrading proteins generated by
certain types of stress (By similarity).
-!- INDUCTION: By heat shock (Probable).
-!- SIMILARITY: Belongs to the clpA/clpB family. ClpE subfamily.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 748
MLCQNCNINE ATIHLYTSVN GQKKQIDLCQ NCYQIMKSGG QEALFGAGNA SNGNSDEPFN
PFNDIFSALH GQDFNGAAST QTPPTQTGGR GPRGPQNPRA KQPKGMLEEF GINITESARR
GEIDPVIGRD EEIKRVIEIL NRRTKNNPVL IGEPGVGKTA VVEGLAQKIV DGDVPQKLQN
KEVIRLDVVS LVQGTGIRGQ FEERMQKLMD EIRKRNDVIM FIDEIHEIVG AGSAGDGNMD
AGNILKPALA RGELQLVGAT TLNEYRIIEK DAALERRMQP VKVDEPSVDE TITILRGIQA
RYEDYHHVKY TDEAIEAAAH LSNRYIQDRF LPDKAIDLLD ESGSKKNLTL KFVDPEDINR
RIADAETKKN EATQAEDFEK AAHFRDQITK LRELQNHEVS DDEIPVITEK DIEQIVEQKT
HIPVGDLKEK EQTQLINLAD DLKAHVIGQD EAVDKIAKAI RRSRVGLGKP NRPIGSFLFV
GPTGVGKTEL AKQLAKELFG SSESMIRFDM SEYMEKHSVA KLIGAPPGYV GYEEAGQLTE
RVRRNPYSLI LLDEIEKAHP DVMHMFLQIL EDGRLTDAQG RTVSFKDSLI IMTSNAGTGK
VEASVGFGAA REGRTKSVLG QLGDFFSPEF MNRFDGIIEF SALSKENLLK IVDLMLDEVN
EQIGRNDIHL SVTQAAKEKL VDLGYNPAMG ARPLRRTIQE NIEDSIADFY IEHPEYKELV
ADLIDDKIVI SNQAQETAET TDEEVPAE