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Description:
DNA polymerase I (EC 2.7.7.7) (POL I).
Molecular weight: 98733
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
07-MAR-2006, entry version 35.
Phylogenetic order:
Bacteria Firmicutes Lactobacillales Streptococcaceae Lactococcus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein DPO1_LACLA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE006442 | AAK06240.1 | - |
| PIR | F86892 | F86892. | |
| HSSP | P52026 | 1L3T | |
| GenomeReviews | AE005176_GR | LL2142.1 | |
| BioCyc | LLAC1360:L0270-MONOMER | -.1 | |
| InterPro | IPR002562 | 3_5_exonuclease. | |
| InterPro | IPR002421 | 5_3_exonuclease. | |
| InterPro | IPR001098 | DNA_pol. | |
| InterPro | IPR002298 | DNA_polI. | |
| InterPro | IPR000513 | Exo_N_I. | |
| InterPro | IPR008918 | HhH2. | |
| InterPro | IPR012337 | RNaseH_fold. | |
| Pfam | PF01367 | 5_3_exonuc | 1. |
| Pfam | PF02739 | 5_3_exonuc_N | 1. |
| Pfam | PF00476 | DNA_pol_A | 1. |
| PRINTS | PR00868 | DNAPOLI. | |
| SMART | SM00474 | 35EXOc | 1. |
| SMART | SM00475 | 53EXOc | 1. |
| SMART | SM00279 | HhH2 | 1. |
| SMART | SM00482 | POLAc | 1. |
| TIGRFAMs | TIGR00593 | pola | 1. |
| PROSITE | PS00447 | DNA_POLYMERASE_A | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; DNA replication; DNA-binding; DNA-directed DNA polymerase; Exonuclease; Hydrolase; Nuclease; Nucleotidyltransferase; Transferase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL1403;
RX MEDLINE=21235186; PubMed=11337471; DOI=10.1101/gr.169701;
RA Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K.,
RA Weissenbach J., Ehrlich S.D., Sorokin A.;
RT "The complete genome sequence of the lactic acid bacterium Lactococcus
RT lactis ssp. lactis IL1403.";
RL Genome Res. 11:731-753(2001).
Feature:
CHAIN 1 877 DNA polymerase I.
/FTId=PRO_0000101243.
Comments:
-!- FUNCTION: In addition to polymerase activity, this DNA polymerase
exhibits 3' to 5' and 5' to 3' exonuclease activity (By
similarity).
-!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
diphosphate + DNA(n+1).
-!- SUBUNIT: Single-chain monomer with multiple functions.
-!- SIMILARITY: Belongs to the DNA polymerase type-A family.
-!- SIMILARITY: Contains 1 3'-5' exonuclease domain.
-!- SIMILARITY: Contains 1 5'-3' exonuclease domain.
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Sequence length: 877
MENKDRLLLI DGSSVAFRAF FALYNQIDRF KAPNGLHTNA IFAFHTMLSS LMERIEPTHV
LIAFDAGKTT FRTEMFADYK GGRSKTPDEF REQLPFIKEM IEKLGIRHYE LANYEADDII
GTLDKMAEAP NVNFDVTIVT GDKDMIQLVD GNTRVEISKK GVAEFEEFTP DYLLEKMGLT
PAQFIDLKAL MGDSSDNYPG VTKVGEKTGL KLLQEFGSLE NLYENVDSLK ASKMKENLIA
DKEMAFLSQQ LATINTKAPI EIGLDDTLLK GKKVDELSQF YDEMGFAQFK SKLLAEAGGE
VTDEKVVDEI DFEIVTDGSI SEKVNADDFF YLETLGENYH REQIVAFAWG NAEKIYVSKN
IDLLTKMKFP ENTYDFKKNR VLLSHLDIEL PLVKFDAMLA KYLISTTEDN KISTIARLFN
SGHLATDEEI FGKGTKIALP DDAVLFEHLA RKIKVLALAK EKMMAELLEN EQEHLLSDME
LPLAEVLAKM EITGIAVSQN TLEEIGAENE EKLASLTREI YDLAGEEFNI NSPKQLGVIL
FEKLQLPVGK KTKTGYSTAV DVLEDLAALS PVVAKILEYR QINKVQSTYV KGLIPQIADD
GKIHTRYVQD LTQTGRLSSV DPNLQNIPVR LEEGRKIRKA FVPSKDSLLL SSDYSQIELR
VLAHISGDEH LIDAFKHGAD IHTSTAMRVF GIEKAEDVTA NDRRNAKAVN FGVVYGISDF
GLARNLGITR KDAKNYIETY FERYPGIKTY MENIVREARD KGFVETMSHR RRKIPDINAR
NFNVRGFAER TAINSPIQGS AADILKIAMI NLDKALSARD FKSKLLLQVH DEIILDVPLE
ELDEIKVLVK QTMEEAIELA VPLKVDENTG KTWYEAK