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Description:
DNA mismatch repair protein mutL.
Molecular weight: 73712
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
02-MAY-2002, sequence version 2.
07-MAR-2006, entry version 22.
Phylogenetic order:
Bacteria Firmicutes Lactobacillales Streptococcaceae Lactococcus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_LACLA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE006449 | AAK06306.1 | ALT_INIT |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | AE005176_GR | LL2208.1 | |
| BioCyc | LLAC1360:L0276-MONOMER | -.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL1403;
RX MEDLINE=21235186; PubMed=11337471; DOI=10.1101/gr.169701;
RA Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K.,
RA Weissenbach J., Ehrlich S.D., Sorokin A.;
RT "The complete genome sequence of the lactic acid bacterium Lactococcus
RT lactis ssp. lactis IL1403.";
RL Genome Res. 11:731-753(2001).
Feature:
CHAIN 1 656 DNA mismatch repair protein mutL.
/FTId=PRO_0000177948.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 656
MGKIIELNEA LANQIAAGEV VERPASVVKE LVENSIDAGS SKIIINVEEA GLRLIEVIDN
GLGLEKEDVA LALRRHATSK IKDSADLFRI RTLGFRGEAL PSIASVSQMT IETSTAEEES
GTKLVAKGGN IETLEPLAKR VGTKISVANL FYNTPARLKY IKSLQAELSH ITDIINRLSL
AHPEISFTLV NEGKEFLKTA GNGDLRQVIA AIYGIGTAKK MRQIKGSDLD FELTGYVSLP
ELTRANRNYI TILINGRFIK NFLLNRAILE GYGNRLMVGR FPFAILSIKI DPTLADVNVH
PTKQEVRLSK ERELMALISK AIDEALSEGV LIPEALENLQ GRAKEKESLS VQTELPLQNN
PLYYDNVRQD FYVREEATFK INKNQASNDS SEQTFDNFTE NQLNTDAVSE KMTDRTVEST
TEITDNSLEN TVSNFEIDFD NEAKISQSST FPQLEYLAQL HATYLLCQSK EGLYLVDQHA
AQERIKYEYW KDKIGEVSME QQILLAPYLF TLAKNDFIVL AEKKDLLHEA GVFLEEYGEN
QFILREHPIW LKETEIEKSI NEMIDIILSS KEFSLKKYRH DLAAMVACKS SIKANHPLDA
ESARALLAEL ATCKNPYSCA HGRPTIVHFS GDDIQKMFRR IQETHRSKAA SWKDFE