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Description:
DNA mismatch repair protein mutS.
Molecular weight: 94272
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
27-APR-2001, sequence version 1.
07-MAR-2006, entry version 29.
Phylogenetic order:
Bacteria Firmicutes Lactobacillales Streptococcaceae Lactococcus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_LACLA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE006450 | AAK06308.1 | - |
| PIR | B86901 | B86901. | |
| HSSP | P23909 | 1OH6 | |
| GenomeReviews | AE005176_GR | LL2210.1 | |
| BioCyc | LLAC1360:L0277-MONOMER | -.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL1403;
RX MEDLINE=21235186; PubMed=11337471; DOI=10.1101/gr.169701;
RA Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K.,
RA Weissenbach J., Ehrlich S.D., Sorokin A.;
RT "The complete genome sequence of the lactic acid bacterium Lactococcus
RT lactis ssp. lactis IL1403.";
RL Genome Res. 11:731-753(2001).
Feature:
CHAIN 1 840 DNA mismatch repair protein mutS.
/FTId=PRO_0000115104.
NP_BIND 601 608 ATP (Potential).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 840
MAEKISPGMQ QYLDIKQDYP DAFLLFRMGD FYELFYDDAV NAAQILELTL TSRNKNSENP
IPMAGVPHHA AAEYIDKLVD LGYKVAVAEQ MEDPKKAVGI VKRAVTQVIT PGTTIDTANS
VDNNFLVAID FKDKHYALSY MDLSTGEFKV TELSEFSAVV GEIASLKARE IVAGFTLDES
QLKVFERQMN LLISEQLEIP ENLLIDLSGL TALENQVASK LLAYVKETQM RDLSHLQEVE
HYEIKDFLQM DFATKSSLEL TANKRENKKH GTLYWLLDET KTAMGTRMLR SWIDRPLISN
SAIQKRMEIV QIFLDHFFER SDLIEALKGV YDLERLASRV SFGKAVPVDF LQLANSLSNV
PAIKYILGML NEAPLEELKS QLDEIPELSG LINSAISENA SRTITEGGII KKGYNAQLDK
YREALENGTS WIAKLEADEK AKTGISTLRI DYNRKDGYYF HITQSQLNSV PEHFYRKATL
KNSERFGSQE LTEIEEIMLE AREKSSSLEY DLFMGLRTET EQYIGRLQAL AKTIAEIDCL
QSLSVVAEKQ GYIRPTLTDG SRIVEIKGGR HAVVEAVMGA QEYVPNDIEL PEQTDIQLIT
GPNMSGKSTY MRQFALTVIM AQIGSFVPAE TANLPIFDAI FTRIGASDNL ISGESTFMVE
MSEANHAIQK ASSRSLIIFD ELGRGTATYD GMALAQAIIE YVHDHIGAKT LFATHYHELT
DLDEALDHLD NVHVATLEQN GNVTFLHKIT EGPADKSYGI HVAKIAGLPQ PLLERADLIL
QKLENKPLPA KKVADEQEQL SLFDFTENSS EIIEKIKRQN VDNMTAREAL NFLWELKDSL