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Description:
Holliday junction ATP-dependent DNA helicase ruvA (EC 3.6.1.-).
Molecular weight: 21167
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
27-APR-2001, sequence version 1.
07-MAR-2006, entry version 37.
Phylogenetic order:
Bacteria Firmicutes Lactobacillales Streptococcaceae Lactococcus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RUVA_LACLA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE006449 | AAK06305.1 | - |
| PIR | G86900 | G86900. | |
| HSSP | P08576 | 1HJP | |
| GenomeReviews | AE005176_GR | LL2207.1 | |
| BioCyc | LLAC1360:L0266-MONOMER | -.1 | |
| HAMAP | MF_00031 | - | 1. |
| InterPro | IPR003583 | HHH1_bd. | |
| InterPro | IPR012340 | OB_NA_bd_sub. | |
| InterPro | IPR000085 | RuvA. | |
| InterPro | IPR011114 | RuvA_C. | |
| Pfam | PF07499 | RuvA_C | 1. |
| Pfam | PF01330 | RuvA_N | 1. |
| ProDom | PD006268 | RuvA | 1. |
| SMART | SM00278 | HhH1 | 2. |
| TIGRFAMs | TIGR00084 | ruvA | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL1403;
RX MEDLINE=21235186; PubMed=11337471; DOI=10.1101/gr.169701;
RA Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K.,
RA Weissenbach J., Ehrlich S.D., Sorokin A.;
RT "The complete genome sequence of the lactic acid bacterium Lactococcus
RT lactis ssp. lactis IL1403.";
RL Genome Res. 11:731-753(2001).
Feature:
CHAIN 1 197 Holliday junction ATP-dependent DNA
helicase ruvA.
/FTId=PRO_0000094641.
Comments:
-!- FUNCTION: The ruvA-ruvB complex in the presence of ATP renatures
cruciform structure in supercoiled DNA with palindromic sequence,
indicating that it may promote strand exchange reactions in
homologous recombination. RuvAB is an helicase that mediates the
Holliday junction migration by localized denaturation and
reannealing. RuvA stimulates, in the presence of DNA, the weak
ATPase activity of ruvB (By similarity).
-!- SUBUNIT: Forms a complex with ruvB.
-!- SIMILARITY: Belongs to the ruvA family.
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Sequence length: 197
MFEYLNGKLV KISPTNIVID VAGIGYLISV ANPYAWSALM NTEVKIYVHQ VIREDAHSLY
GFVNEAEKAL FLRLISVSGI GPKSALAIIA AADNEGLITA IDNSDIKYLT KFPGVGKKTA
MQMVLDLAGK FDATGTVGIS LLDAGPAGNL ALEEAIEALQ ALGYKATELK KIEKKLAQET
GLTSEEYIKS ALKLMMK