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Description:
Holliday junction ATP-dependent DNA helicase ruvB (EC 3.6.1.-).
Molecular weight: 37633
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
31-OCT-2003, sequence version 2.
07-MAR-2006, entry version 38.
Phylogenetic order:
Bacteria Firmicutes Lactobacillales Streptococcaceae Lactococcus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RUVB_LACLA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE006449 | AAK06304.1 | ALT_INIT |
| PIR | F86900 | F86900. | |
| HSSP | Q56313 | 1IN5 | |
| GenomeReviews | AE005176_GR | LL2206.1 | |
| BioCyc | LLAC1360:L0267-MONOMER | -.1 | |
| HAMAP | MF_00016 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR003959 | AAA_ATPase_centr. | |
| InterPro | IPR004605 | RuvB. | |
| InterPro | IPR008823 | RuvB_C. | |
| InterPro | IPR008824 | RuvB_N. | |
| InterPro | IPR011991 | Wing_hlx_DNA_bd. | |
| Pfam | PF00004 | AAA | 1. |
| Pfam | PF05491 | RuvB_C | 1. |
| Pfam | PF05496 | RuvB_N | 1. |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR00635 | ruvB | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; Helicase; Hydrolase; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL1403;
RX MEDLINE=21235186; PubMed=11337471; DOI=10.1101/gr.169701;
RA Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K.,
RA Weissenbach J., Ehrlich S.D., Sorokin A.;
RT "The complete genome sequence of the lactic acid bacterium Lactococcus
RT lactis ssp. lactis IL1403.";
RL Genome Res. 11:731-753(2001).
Feature:
CHAIN 1 333 Holliday junction ATP-dependent DNA
helicase ruvB.
/FTId=PRO_0000165543.
NP_BIND 59 66 ATP (Potential).
Comments:
-!- FUNCTION: The ruvA-ruvB complex in the presence of ATP renatures
cruciform structure in supercoiled DNA with palindromic sequence,
indicating that it may promote strand exchange reactions in
homologous recombination. RuvAB is an helicase that mediates the
Holliday junction migration by localized denaturation and
reannealing (By similarity).
-!- SUBUNIT: Forms a complex with ruvA (By similarity).
-!- SIMILARITY: Belongs to the ruvB family.
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Sequence length: 333
MNDILNKEPM EEDYGIEKSL RPQFFNQYIG QDKVKEQLEI FIKAAKMREE VLDHVLLFGP
PGLGKTTMAF VIANELGVNI KQTAGPAIEK PGDLVAILNE LEPGDVLFID EIHRMPMQVE
EVLYSAMEDF YIDIMLGSGD GSRSVHLDLP PFTLVGATTR AGMLSNPLRA RFGISSHMEY
YQERDLEEIV KRTADIFEVE VIDNAALEIA LRSRGTPRIA NRLLKRVRDF AQIMGDGRVD
KAITDKALSI LDVDAAGLDY IDQKILRTMI EMYHGGPVGI GTLAVNIAED RETVEDMYEP
YLIQKGFLMR TKQGRKVTQR AYEHLGYVYN EED