|
|
|
|
|
|
Description:
Uracil-DNA glycosylase (EC 3.2.2.-) (UDG).
Molecular weight: 24629
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
27-APR-2001, sequence version 1.
07-MAR-2006, entry version 37.
Phylogenetic order:
Bacteria Firmicutes Lactobacillales Streptococcaceae Lactococcus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG_LACLA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE006261 | AAK04332.1 | - |
| PIR | B86654 | B86654. | |
| HSSP | P13051 | 1AKZ | |
| GenomeReviews | AE005176_GR | LL0234.1 | |
| BioCyc | LLAC1360:L32653-MONOMER | -.1 | |
| HAMAP | MF_00148 | - | 1. |
| InterPro | IPR003249 | U_glycsylse_notp. | |
| InterPro | IPR002043 | UDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| PANTHER | PTHR11264 | U_glycsylse_notp.1 | 1. |
| Pfam | PF03167 | UDG | 1. |
| ProDom | PD001589 | U_glycsylse_notp | 1. |
| TIGRFAMs | TIGR00628 | ung | 1. |
| PROSITE | PS00130 | U_DNA_GLYCOSYLASE | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL1403;
RX MEDLINE=21235186; PubMed=11337471; DOI=10.1101/gr.169701;
RA Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K.,
RA Weissenbach J., Ehrlich S.D., Sorokin A.;
RT "The complete genome sequence of the lactic acid bacterium Lactococcus
RT lactis ssp. lactis IL1403.";
RL Genome Res. 11:731-753(2001).
Feature:
CHAIN 1 219 Uracil-DNA glycosylase.
/FTId=PRO_0000176107.
ACT_SITE 62 62 Proton acceptor (By similarity).
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Sequence length: 219
MKKTDWSQPL RNRLAEDYFP KMIEFINQTY QEGKVYPPEN QIFRAIELTP LAQTKVIIVG
QDPYPQPGKA QGLAFSYPAT FKVNRPDSIV NIQKELREEG FSKDDSDLTA WAEQGVLLLN
AVLTVPEFAS NAHAGKIWEP LTDEIIKIAS DDERPKVFIL WGGFARKKAK LIDGSKHLIL
EAAHPSPLSA SRGFFGSHPF SKTNEFLVES GQSPIDWSK