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Description:
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A).
Molecular weight: 10430
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
27-APR-2001, sequence version 1.
07-MAR-2006, entry version 38.
Phylogenetic order:
Bacteria Firmicutes Lactobacillales Streptococcaceae Lactococcus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRA_LACLA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE006412 | AAK05916.1 | - |
| PIR | B86852 | B86852. | |
| GenomeReviews | AE005176_GR | LL1818.1 | |
| BioCyc | LLAC1360:L0256-MONOMER | -.1 | |
| HAMAP | MF_00205 | - | 1. |
| InterPro | IPR003439 | ABC_transp_like. | |
| InterPro | IPR004602 | UvrA_ABC. | |
| Pfam | PF00005 | ABC_tran | 1. |
| TIGRFAMs | TIGR00630 | uvra | 1. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | 2. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 2. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL1403;
RX MEDLINE=21235186; PubMed=11337471; DOI=10.1101/gr.169701;
RA Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K.,
RA Weissenbach J., Ehrlich S.D., Sorokin A.;
RT "The complete genome sequence of the lactic acid bacterium Lactococcus
RT lactis ssp. lactis IL1403.";
RL Genome Res. 11:731-753(2001).
Feature:
CHAIN 1 940 UvrABC system protein A.
/FTId=PRO_0000093056.
DOMAIN 341 592 ABC transporter 1.
DOMAIN 606 935 ABC transporter 2.
NP_BIND 33 40 ATP (Potential).
ZN_FING 252 279 C4-type.
NP_BIND 639 646 ATP (Potential).
ZN_FING 738 764 C4-type.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrA is an ATPase and a DNA-binding
protein. A damage recognition complex composed of 2 uvrA and 2
uvrB subunits scans DNA for abnormalities. When the presence of a
lesion has been verified by uvrB, the uvrA molecules dissociate
(By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrB during the search for
lesions (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily.
-!- SIMILARITY: Contains 2 ABC transporter domains.
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Sequence length: 940
MPQDKIVIHG AREHNLKNID VEIPRDKLVV VTGVSGSGKS SLAFETLYAE GQRRYVESLS
AYARQFLGNM DKPDVDSIDG LSPAISIDQK TTSKNPRSTV GTVTEINDYL RLLYARVGTP
YCVNGHGKIS AQSVEEIVEQ ILELPEKTRL QILAPVVRTK KGTHVKMFER IQKDGYVRVR
VDGEVYDISE VPELDKNKKH NIEIVIDRIV VKEGIRSRLF DSVEAALHQA EGYVIVDKMD
GSELLFSEFY ACPVCGFTVP ELEPRLFSFN APFGSCPDCD GLGVKLEPDV DLLIPDTSKT
LREGAIIYWY GKASTYYPAL LEQAMEQFGI DLDRPWEKLS EKEQQIVLYG NGDKLFHFLH
EGDFGLRDQD MTFVGVIPNL WRRYRSGMSE SAREMARSYM TELTCTTCHG YRLNDQALSV
KVGEKNIAEF SILSIGDTLD YVKSLVLSAN NEIIAKPILK EIKDRLTFLK NVGLDYLTLS
RSSGTLSGGE SQRIRLATQI GSNLSGVLYI LDEPSIGLHQ RDNDRLIESL QKMRDLGNTL
IVVEHDEDTM MAADWLIDVG PGAGDLGGEI IASGTPKQVM KNKKSLTGQY LSGKRAIPVP
EKRRAIDKKK MVKITGASEN NLQNLDVEFP MGVMTAVTGV SGSGKSTLVN SILKKSLAQK
LNHNSEKPGK HKKITGYEGI ERLIDIDQSP IGRTPRSNPA TYTSVFDDIR DLFANTNEAK
IRGYKKGRFS FNVKGGRCEA CSGDGIIKIE MHFLPDVYVP CEVCHGRRYN SETLEVHYKG
KNISEVLDMR VSDGLEFFRH IPKIERKLQT IVDVGLGYVT LGQSATTLSG GEAQRMKLAS
ELQKRSNGKA FYILDEPTTG LHSEDIATLI QVLDRLVEQG NTIVVIEHNL DVIKTADYII
DLGPEGGAGG GTILAKGRPE EVAKVADSYT GQYLKAKLEK