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Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 76425
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
27-APR-2001, sequence version 1.
07-MAR-2006, entry version 32.
Phylogenetic order:
Bacteria Firmicutes Lactobacillales Streptococcaceae Lactococcus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_LACLA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE006318 | AAK04938.1 | - |
| PIR | H86729 | H86729. | |
| GenomeReviews | AE005176_GR | LL0840.1 | |
| BioCyc | LLAC1360:L0258-MONOMER | -.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL1403;
RX MEDLINE=21235186; PubMed=11337471; DOI=10.1101/gr.169701;
RA Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K.,
RA Weissenbach J., Ehrlich S.D., Sorokin A.;
RT "The complete genome sequence of the lactic acid bacterium Lactococcus
RT lactis ssp. lactis IL1403.";
RL Genome Res. 11:731-753(2001).
Feature:
CHAIN 1 668 UvrABC system protein C.
/FTId=PRO_0000138307.
DOMAIN 196 231 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 668
MNQTIKAKLE LLPDSPGCYL HKDKNGTVIY VGKAKNLKNR VRSYFHGSHN TKTELLVSEI
EDLEWIVVGS NIESLVLEIN LIQRYKPKYN IMLKDDKYYP FLKITNEKYP RLLVVRKVQK
DGATYFGPYP DVKAANEVKR LLDRIFPFRK CGLHEKKVCF YFHIHQCLCP VVNHVDPQVF
KDMTQEVKEF LTGSDKKIVN ELEAKMMVSS DNMEFEQAAE YRDVIKAIGT LRTKQRVMNQ
DLKDRDVFGY YVDKGWMCVQ VFFVRQGKLI QRDVNMFPYY NDAEEDFLTY IGQFYQDNNH
MMPREIFIPQ DIDKESVEAV VAASQEGNLL TKAQAKEVDA KVFTAKTLKF SDQKDVEQSI
VKLDKELSAE KRLSSLLAKT QIVQPSRGEK KQLVNMATKN AQSQLQLKFD VAERDILKTT
KAVENLGKIL GIPKPVRIES FDNSNIMGTS PVSAMVVFID GKPSKKDYRK YKIKTVVGAD
DYASMREVMT RRYSRALKEE TALPDLIAMD GGAGQVNITK QVLKELGLSI PVAGMQKNDK
HQTSELLFGD PLDVVPLSRQ SQEFFLLTRI QDEVHRFAIT FHRQLRGKNT FSSKLDGIVG
LGPKRKQKLL TTFKNLKAIE EASVQEVAEA DIPYEVAERV KTTLSGPIQE NENWESLKDN
VPLLEGKK