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Description:
DNA mismatch repair protein mutS.
Molecular weight: 10109
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
01-JUN-2003, sequence version 1.
07-MAR-2006, entry version 22.
Phylogenetic order:
Bacteria Firmicutes Bacillales Bacillaceae Bacillus Bacillus cereus group.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_BACAN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE016879 | AAP27638.1 | - |
| EMBL | AE017334 | AAT33019.1 | - |
| EMBL | AE017225 | AAT55922.1 | - |
| HSSP | P23909 | 1NG9 | |
| GenomeReviews | AE016879_GR | BA3905.1 | |
| GenomeReviews | AE017225_GR | BAS3618.1 | |
| GenomeReviews | AE017334_GR | GBAA3905.1 | |
| TIGR | BA3905 | -. | |
| TIGR | GBAA3905 | -. | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames / isolate Porton;
RX MEDLINE=22608414; PubMed=12721629; DOI=10.1038/nature01586;
RA Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T.,
RA Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R.,
RA Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M.,
RA Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L.,
RA DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H.,
RA Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D.,
RA Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F.,
RA Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C.,
RA Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O.,
RA Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M.,
RA Hanna P.C., Kolstoe A.-B., Fraser C.M.;
RT "The genome sequence of Bacillus anthracis Ames and comparison to
RT closely related bacteria.";
RL Nature 423:81-86(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames ancestor;
RA Ravel J., Rasko D.A., Shumway M.F., Jiang L., Cer R.Z., Federova N.B.,
RA Wilson M., Stanley S., Decker S., Read T.D., Salzberg S.L.,
RA Fraser C.M.;
RT "Bacillus anthracis comparative genomics.";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sterne;
RA Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K.,
RA Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R.,
RA Richardson P., Rubin E., Tice H.;
RT "Complete genome sequence of Bacillus anthracis Sterne.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
Feature:
CHAIN 1 892 DNA mismatch repair protein mutS.
/FTId=PRO_0000115066.
NP_BIND 607 614 ATP (Potential).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 892
MTQYTPMIQQ YLKVKADYQD AFLFFRLGDF YEMFFEDAVK AAHELEITLT SRDGGSSERI
PMCGVPYHAA KNYIEQLVEK GYKVAVCEQV EDPKTAKGVV RREVVQLITP GTMMEGRTID
EKENNFLAAL THFEDGSYAL ACNDLTTGQN TVTLLTGSVE DILLEVYATG SKEIVVDSSF
SKDELNKLTE TLKMTISYED ATAIPEGLEH LVKNVSQAKL IKAVGRLFNY VIRTQKRSLD
HLQPVEIYYT NQFMKIDVHS KRNLELTETL RTKEKTGSLL WLLDKTKTAM GGRMLKQWME
RPLIQKERIE ERLEMVETFV NDYFLREDLK EKLKEVYDLE RLAGKVAFGN VNARDLLQLR
RSLLQVPAIL EAISLLDNAY AARLIQGADP CESLTELLGR SIQENPPLSI KDGDIIKDGY
NDKLDQYRYV SKNGKTWIAE LEKRERDITG IKSLKIGYNR IFGYYIEVTK ANLGALPEGR
YERKQTLANA ERFITDELKE KETLILEAEE KIVQLEYDLF TALREEVKVF IPKLQHLAKV
ISELDVLQSF ATVSEEEQFV KPVLTTKREI FIKDGRHPVV EKVLNGKLYV PNDCIMPENM
DVFLITGPNM SGKSTYMRQL ALVTVMSQIG CFVPATEAVL PVFDQIFTRI GAADDLISGQ
STFMVEMLEA KNAIANASER SLILFDEIGR GTSTYDGMAL AQAIIEHIHD QIGAKTLFST
HYHELTVLED SLDQLKNVHV SAIEENGKVV FLHKIQDGAA DKSYGIHVAQ LAELPDSLIA
RAKEVLAQLE GQEEIVIPKR VEVKAQEQEV IPEPIVVKEE PIEIEETKVD NEEESQLSFF
GAEQSSKKQD KPALDAKETA VLTQIKKIDL LDMTPLEAMN ELYRLQKKLK KG