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Description:
UV DNA damage endonuclease (EC 3.-.-.-) (UV-endonuclease) (UVED).
Molecular weight: 36818
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 ) pyrimidine dimer repair( GO:0006290 )
Important dates:
25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
25-JUL-2003, sequence version 2.
07-MAR-2006, entry version 20.
Phylogenetic order:
Bacteria Firmicutes Bacillales Bacillaceae Bacillus Bacillus cereus group.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVSE_BACAN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE016879 | AAP29234.1 | ALT_INIT |
| EMBL | AE017334 | AAT34738.1 | ALT_INIT |
| EMBL | AE017225 | AAT57485.1 | ALT_INIT |
| GenomeReviews | AE016879_GR | BA5592.1 | |
| GenomeReviews | AE017225_GR | BAS5196.1 | |
| GenomeReviews | AE017334_GR | GBAA5592.1 | |
| TIGR | BA5592 | -. | |
| TIGR | GBAA5592 | -. | |
| HAMAP | MF_00606 | - | 1. |
| InterPro | IPR004601 | UvdE. | |
| Pfam | PF03851 | UvdE | 1. |
| TIGRFAMs | TIGR00629 | uvde | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Endonuclease; Hydrolase; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames / isolate Porton;
RX MEDLINE=22608414; PubMed=12721629; DOI=10.1038/nature01586;
RA Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T.,
RA Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R.,
RA Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M.,
RA Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L.,
RA DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H.,
RA Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D.,
RA Benton J.L., Mahamoud Y., Jiang L., Hance I.R., Weidman J.F.,
RA Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C.,
RA Hazen A., Cline R.T., Redmond C., Thwaite J.E., White O.,
RA Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M.,
RA Hanna P.C., Kolstoe A.-B., Fraser C.M.;
RT "The genome sequence of Bacillus anthracis Ames and comparison to
RT closely related bacteria.";
RL Nature 423:81-86(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames ancestor;
RA Ravel J., Rasko D.A., Shumway M.F., Jiang L., Cer R.Z., Federova N.B.,
RA Wilson M., Stanley S., Decker S., Read T.D., Salzberg S.L.,
RA Fraser C.M.;
RT "Bacillus anthracis comparative genomics.";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sterne;
RA Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K.,
RA Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R.,
RA Richardson P., Rubin E., Tice H.;
RT "Complete genome sequence of Bacillus anthracis Sterne.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
Feature:
CHAIN 1 317 UV DNA damage endonuclease.
/FTId=PRO_0000215031.
CONFLICT 192 192 C -> Y (in Ref. 3).
Comments:
-!- FUNCTION: Component in a DNA repair pathway. Removal of UV-light
damaged nucleotides. Recognizes pyrimidine dimers and cleave a
phosphodiester bond immediately 5' to the lesion (By similarity).
-!- SIMILARITY: Belongs to the uve1/uvsE family.
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Sequence length: 317
MIMRFGYVSH AMALWDCSPA KTITFTSFQK LSKQEREDKL YDVTKQNLEH TIRILHYNIA
HEIPLYRLSS SIVPLATHPE VEFDYIGAFT PLWRKIGALI KEHNLRISFH PNQFTLFTSD
KPHITTNAIT DMTYHYKVLD AIGIADSSYI NIHVGGAYGN KEKAIERFHE NIKKLPAHIK
KQMTLENDDK TCTTAETLSI CQKEKIPFVF DYHHHMANLC EEPLEELLPA IFETWSHTNI
VPKVHISSPK SKKEFRAHAE YIDLEFIKPF LHVAKKINHN FDIMIESKQK DLAMLQFIQE
LSSIRGIKRI SSSTLQW