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Description:
DNA polymerase I (EC 2.7.7.7) (POL I).
Molecular weight: 10550
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-JUN-1998, sequence version 1.
07-MAR-2006, entry version 42.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Spirochaetaceae Borrelia Borrelia burgdorferi group.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein DPO1_BORBU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001156 | AAC66909.1 | - |
| PIR | C70168 | C70168. | |
| HSSP | P19821 | 1KTQ | |
| GenomeReviews | AE000783_GR | BB0548.1 | |
| TIGR | BB0548 | -. | |
| BioCyc | BBUR139:BB0548-MONOMER | -.1 | |
| LinkHub | O51498 | -.1 | |
| InterPro | IPR002562 | 3_5_exonuclease. | |
| InterPro | IPR002421 | 5_3_exonuclease. | |
| InterPro | IPR001098 | DNA_pol. | |
| InterPro | IPR002298 | DNA_polI. | |
| InterPro | IPR000513 | Exo_N_I. | |
| InterPro | IPR008918 | HhH2. | |
| InterPro | IPR012337 | RNaseH_fold. | |
| Pfam | PF01612 | 3_5_exonuc | 1. |
| Pfam | PF01367 | 5_3_exonuc | 1. |
| Pfam | PF02739 | 5_3_exonuc_N | 1. |
| Pfam | PF00476 | DNA_pol_A | 1. |
| PRINTS | PR00868 | DNAPOLI. | |
| SMART | SM00474 | 35EXOc | 1. |
| SMART | SM00475 | 53EXOc | 1. |
| SMART | SM00279 | HhH2 | 1. |
| SMART | SM00482 | POLAc | 1. |
| TIGRFAMs | TIGR00593 | pola | 1. |
| PROSITE | PS00447 | DNA_POLYMERASE_A | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; DNA replication; DNA-binding; DNA-directed DNA polymerase; Exonuclease; Hydrolase; Nuclease; Nucleotidyltransferase; Transferase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35210 / B31;
RX MEDLINE=98065943; PubMed=9403685; DOI=10.1038/37551;
RA Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K.,
RA Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D.,
RA Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J.,
RA Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D.,
RA Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A.,
RA Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K.,
RA Roberts K.M., Hatch B., Smith H.O., Venter J.C.;
RT "Genomic sequence of a Lyme disease spirochaete, Borrelia
RT burgdorferi.";
RL Nature 390:580-586(1997).
Feature:
CHAIN 1 908 DNA polymerase I.
/FTId=PRO_0000101236.
DOMAIN 1 318 5'-3' exonuclease.
DOMAIN 319 531 3'-5' exonuclease.
REGION 532 908 Polymerase.
Comments:
-!- FUNCTION: In addition to polymerase activity, this DNA polymerase
exhibits 3' to 5' and 5' to 3' exonuclease activity (By
similarity).
-!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
diphosphate + DNA(n+1).
-!- SIMILARITY: Belongs to the DNA polymerase type-A family.
-!- SIMILARITY: Contains 1 3'-5' exonuclease domain.
-!- SIMILARITY: Contains 1 5'-3' exonuclease domain.
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Sequence length: 908
MKELYLIDAL NIIFRNYHVM KNYPLLNTQG ENVNAFIGFF KTLFFIIKEK NPEHLIITFD
SEVPTFRKQK YPSYKATRDL PPDDLIPQIG WIKEGLLKAK IPIFEMEGYE ADDLLASFAK
KAAKNNYLTY IISPDKDLLQ TMSEYVKILK IENNSFIEMD NEYVTKKFGV NSFQIKDYLA
IVGDRSDNIP GIKGIGAKGA ANLLREFKTL DGIYSNLEII NKKHRELLIK EKENAFLSYE
LVSLEENLKI PEIENFALKN FSEEIISLFE KHSAIALIKT YKKDILKQEK ENADQKSLFK
QEPTTNSLDD INTIDTENVK YRSITTKIEL DDLIESLKKA KYISIDTETS SLDTYTAKLI
GISISFKEFE GYYIPIEAKG KIYIEKNYII QKFNNLFESN PKIIGQNYKF DYKILKNNGF
NPIPPYFDTM IAAYLIDTNS KVSLDFLAEK YLMHKNIKYE DVIQKNDNFA NISLEMATSY
SSEDADITFR LFNIFTKKLK EDKLDKLMHE IEMPFNKVII EMEENGIYLD KEYLKEYGKE
LGKELEAIEN EIIKSIGIDF NLNSPKQMHE ILFEKLNLKL PEKMKKDSTD IKVLESLREQ
HESIENLIKY RQIAKLKSTY TDNLIELINY KTNRLHTSFI QTKTATGRIT SINPNLQNIP
IKDEKGRKIR KAFKPENGNI FISADYSQIE LAILAHLSQD EVLIKAFENN KDIHTETASK
LFKIEEKEIT PNLRRIAKSI NFGIIYRMSD FRLAKELGIT KEEAKGFINS YFDSYPKIKE
FIINQINFVR NAGYSETILK RRRYIKEINS NNYLERSAAE RIAINSIIQG SAADIMKIAM
VKVFNEFKSK KMESKILLQV HDEMLIESPI EEENEVKKIL KIMMETAYTL NLPLRANIET
GKSWGEIH