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Description:
Exodeoxyribonuclease V beta chain (EC 3.1.11.5).
Molecular weight: 1378
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-JUN-1998, sequence version 1.
07-MAR-2006, entry version 34.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Spirochaetaceae Borrelia Borrelia burgdorferi group.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein EX5B_BORBU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001164 | AAC66981.1 | - |
| PIR | H70178 | H70178. | |
| HSSP | P56255 | 1PJR | |
| GenomeReviews | AE000783_GR | BB0633.1 | |
| TIGR | BB0633 | -. | |
| BioCyc | BBUR139:BB0633-MONOMER | -.1 | |
| InterPro | IPR004586 | RecB. | |
| InterPro | IPR000212 | UvrD-helicase. | |
| PANTHER | PTHR11070 | UvrD-helicase.1 | 2. |
| Pfam | PF00580 | UvrD-helicase | 1. |
| TIGRFAMs | TIGR00609 | recB | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; Endonuclease; Exonuclease; Helicase; Hydrolase; Nuclease; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35210 / B31;
RX MEDLINE=98065943; PubMed=9403685; DOI=10.1038/37551;
RA Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K.,
RA Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D.,
RA Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J.,
RA Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D.,
RA Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A.,
RA Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K.,
RA Roberts K.M., Hatch B., Smith H.O., Venter J.C.;
RT "Genomic sequence of a Lyme disease spirochaete, Borrelia
RT burgdorferi.";
RL Nature 390:580-586(1997).
Feature:
CHAIN 1 1169 Exodeoxyribonuclease V beta chain.
/FTId=PRO_0000102039.
NP_BIND 18 25 ATP (Potential).
Comments:
-!- FUNCTION: Required for efficient DNA repair; it catalyzes the
unwinding of double-stranded DNA and the cleavage of single-
stranded DNA and it stimulates local genetic recombination. All of
these activities require concomitant hydrolysis of ATP (By
similarity).
-!- CATALYTIC ACTIVITY: Exonucleolytic cleavage (in the presence of
ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-
phosphooligonucleotides.
-!- SUBUNIT: Consist of three subunits; recB, recC and recD (By
similarity).
-!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
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Sequence length: 1169
MNKILEKIQN NTTILIEASA GTGKTHILEN VVINLIKTKL YSINEILVLT FTKKATEEMH
TRILKVIENA YSNSKTNEIL KEAYEQSKKL FISTINKFAL HALNNFQIET ENYSKYKPKE
KFSKEIDEIV YDFLRKSDSL IQALDIKDYE LKVFKSDAKK TEEIVLKIKK AYERDTTQEL
GDWLKTQTAF ENILLKKEEL IKDYNKIIED LDKMTKDEIL SFYNKHIQTG KLEIEYSKEN
DIFKIAETLL KNKFFSTLIE KETKKNSKLS PKELKIKNDL ICLGINIKHE KYKSEDNRNK
NRNNLKQYVI LKVEYKILKY IEKELKKTIK STNTIDQNYI ISNLKNYLKS EDKKLLNAIK
NRYKIILIDE AQDLSLIQIE IFKILKTAGI KLIFIADPKQ IIYSFRKADI SFYNKEIKNK
INTDARIVLK INHRSSKKLI GPLNKIFNNI YNNAIADEIE KIDFTNSLPN QKNDNNKIVI
NGQEIEGINI ITTNTESEED IYQKTALTIK YLLAYGKIAE NNKIRNIKMQ DIKVLCRGKN
EINLIDKALK KEQIQTNKTQ EKFLKTKEFS EIFYIIKCLD RKQSFKTLNY ILSSKILNVP
WNLQRILIKQ DKICLIEEFI ENIIVLLEKN EITLINAINK ITFEKNLWIK IANITKDQKI
IEWAKNKINY KGLLIKEGKL ENLKTYETTL EIISKIYHKE QNIQSLISTL ESLIINEEPE
EIEEKINNIN NDNESIELMT IHKSKGLGMN IVFLLNTTPI ENSNFFSKKN QFYKFYQDGK
IEYDFFKLEE NKKYARLKIL SEEKNIFYVG ATRAKFALFI IKINSITSKL LEIAKIFTID
DIKHDFNIHE FIGQKRFNKK KYNTNVNTKL IPPKPIIKNM FKKEYTSSFS SLTAQAHHKE
FYENYDFKNI NYEKETELDY EPGLEETLPK GKDIGNILHA AMEEIIFSTA KDTFDNFKKN
NIEIIEKQIQ KINSNLNTIE IQNSLAKMIY NILTYNIRAI NTRLCDIEEL QKEMEFLIKI
NPEFQKQKYL FDKHFEDLHI KLSDGYLKGI VDLIFKANNK IYILDYKTNY LGKNKEDYNI
TNLENTIKKE YYDLQYKIYA LGIKKILFKN KKEYNQKFGG IIYLFTRAFE DNIECLKSKF
ENGIYFNLPK FNDVDLDKII LELGIKRHL