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Description:
Transcription-repair coupling factor (EC 3.6.1.-) (TRCF) (ATP-dependent helicase mfd).
Molecular weight: 1307
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-JUN-1998, sequence version 1.
07-MAR-2006, entry version 37.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Spirochaetaceae Borrelia Borrelia burgdorferi group.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MFD_BORBU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001163 | AAC66973.1 | - |
| PIR | F70177 | F70177. | |
| HSSP | Q9WY48 | 1GM5 | |
| GenomeReviews | AE000783_GR | BB0623.1 | |
| TIGR | BB0623 | -. | |
| BioCyc | BBUR139:BB0623-MONOMER | -.1 | |
| InterPro | IPR003711 | CarD_TRCF. | |
| InterPro | IPR001410 | DEAD. | |
| InterPro | IPR011545 | DEAD/DEAH_N. | |
| InterPro | IPR001650 | Helicase_C. | |
| InterPro | IPR004576 | Mfd. | |
| InterPro | IPR005118 | TRCF. | |
| Pfam | PF02559 | CarD_TRCF | 1. |
| Pfam | PF00270 | DEAD | 1. |
| Pfam | PF00271 | Helicase_C | 1. |
| Pfam | PF03461 | TRCF | 1. |
| SMART | SM00487 | DEXDc | 1. |
| SMART | SM00490 | HELICc | 1. |
| TIGRFAMs | TIGR00580 | mfd | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35210 / B31;
RX MEDLINE=98065943; PubMed=9403685; DOI=10.1038/37551;
RA Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K.,
RA Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D.,
RA Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J.,
RA Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D.,
RA Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A.,
RA Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K.,
RA Roberts K.M., Hatch B., Smith H.O., Venter J.C.;
RT "Genomic sequence of a Lyme disease spirochaete, Borrelia
RT burgdorferi.";
RL Nature 390:580-586(1997).
Feature:
CHAIN 1 1125 Transcription-repair coupling factor.
/FTId=PRO_0000102163.
NP_BIND 610 617 ATP (Potential).
MOTIF 711 714 DEEQ box.
Comments:
-!- FUNCTION: Necessary for strand-specific repair. A lesion in the
template strand blocks the RNA polymerase complex (RNAP). The
RNAP-DNA-RNA complex is specifically recognized by TRCF which
releases RNAP and the truncated transcript; the TCRF may replace
RNAP at the lesion site and then recruit the uvrA/B/C repair
system (By similarity).
-!- SIMILARITY: In the N-terminal section; belongs to the uvrB family.
-!- SIMILARITY: In the C-terminal section; belongs to the helicase
family. RecG subfamily.
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Sequence length: 1125
MNIDEELTTI LKNNSNLKKM KEFLEQNIFF SLTGYEGFFK AFLIKKIKEY SKTGKIILIV
KDEHTLDKIK NDLQVITNQI FELNYFSPLV YKGIGSKSTI FNERIKFLFN FYKKNPGIYI
TVLKSLLSKI PDKNTLLKNI YKIEKNTNIN TADIEKTLIT LGYEKTLRVT IPGEFTVKGE
IIDIYPFGEQ NPIRIALNFD KIEEIKKFNP LTQLKHDNEI LEFQILPKKE IIWDDKTINT
LKTKIKSVEY KKILEELDFK KETKTEEMFY PLVANTYLGD EIEKHTPIVN FEINNFEKEI
EKIHQEYEKL YKEAEEAGKN IIDPKRILLN YKTFNLKSDV LFSKIKSLKS KETIEFKIES
ERNFFSNIAL TKEEFENWLK NGFKIIIAAE SESQKEKLKY IFKELPKVSI EVLKISSSLI
IEKEKIAIIL ESNIFNTGQK INKAFESSKT KAIDSFVEIE KNSHVVHINH GIGIFRQIKR
IKTSSLEKDY IEIEYAEGEK LFIPIEQTNL IQKYIGSDPK NIKLDKISSK TWIKNKANAK
KRIEEIADKL IELYSKRESI KGIKYPEDNE LQLLFESEFP YDETPDQIRA IKEIKEDMMS
FKVMDRLLCG DVGFGKTEVA MRAAFKAVMG NKQVIVLSPT TILAEQHFNT FKKRFKNFPI
KIEVLSRFIK NNAESRILKE LKSGKIDIII GTHKILSKKF TCKNLGLIII DEEQRFGVKE
KEKLKEIRIS VDCLALSATP IPRSLHMSLI KLRDISVLKI PPQNRVKIEA YLESFSELLI
KHAIESELSR DGQVFLVNHN IEELYYLKTL IERLTPYARI AIIHGKLTGE EIENIMHNFI
KKAYQILLAT TIIENGIDIP NANTIIINNA NKFGLAQLYQ LKGRVGRGSQ KAYAYFLYQD
SEKLNERSIE RLRAITEFSE LGAGFKIAMK DMEIRGVGNL LGREQHGEIE SIGLDYYLTM
LNKAIEKKMG KISSDEEEVD IKINYSGFIP ENYAKNEQDK ILIYKKIFKI QTEEESKKIR
SELHNDFGPI PEEINSLLML AELKILAKDL NITKLKEKNR ALEIEYKNIE SIPMEKIIEI
LQKHPNLLIL NPSYQKSIFL SFKNIEKSEK INYIYKNINL LKTST