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Description:
DNA mismatch repair protein mutL.
Molecular weight: 71543
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-JUN-1998, sequence version 1.
07-MAR-2006, entry version 33.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Spirochaetaceae Borrelia Borrelia burgdorferi group.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_BORBU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001131 | AAC66594.1 | - |
| PIR | C70126 | C70126. | |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | AE000783_GR | BB0211.1 | |
| TIGR | BB0211 | -. | |
| BioCyc | BBUR139:BB0211-MONOMER | -.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35210 / B31;
RX MEDLINE=98065943; PubMed=9403685; DOI=10.1038/37551;
RA Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K.,
RA Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D.,
RA Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J.,
RA Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D.,
RA Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A.,
RA Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K.,
RA Roberts K.M., Hatch B., Smith H.O., Venter J.C.;
RT "Genomic sequence of a Lyme disease spirochaete, Borrelia
RT burgdorferi.";
RL Nature 390:580-586(1997).
Feature:
CHAIN 1 610 DNA mismatch repair protein mutL.
/FTId=PRO_0000177928.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 610
MNKIRFLDKY LVQKIAAGES IDRPCSILRE LLDNSIDSGA TKIEVFLEEG GIQKILIIDN
GSGISKEDLK ICYLPHTTSK ISSEEDLRKI ETLGFRGEAL SSIAICSNIS ITSSTTSNES
YQIEVENGIE KCFKKQPAIN GTIVDVTKIF HNFPARKRFL KQEPIETKMC LKVLEEKIIT
HPEINFEINL NQKLRKIYFK ESLIDRVQNV YGNVIENNKF RVLKKEHDNI KIEIFLAPDN
FSKKSKRHIK TFVNRRPIDQ KDLLEAITNG HSRILSPGNF PICYLFLEIN PEYIDFNVHP
QKKEVRFYNL PFLFKLISDN INNFFDKNIN NYQDIIIKRQ LTEDDHLIEM TNQPENFNKI
NTYDIPQNNN LETEDVNEPN KNTTQSNIDL RRYNSIIQNR PTLRENIGNI FSDNFLEFEE
PPNKNEKEEI KFNYIGQIFS EFLIVEKINE IYFIDQHAVH EKIIYEKLRN SKKNVQKLLV
PIEFTVVDKN IEEIIDSEIE EYKQMDIIIS KIGPKKYQLE SIPNICSQYE NTLINFFQSR
RSRTINSLES DLYATIACRK AVKRNDMLSA EFSKFLINEF FKLEIKHCPH GRKIYYKISK
FELEKKVDRA