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Description:
DNA mismatch repair protein mutS.
Molecular weight: 99749
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-JUN-1998, sequence version 1.
07-MAR-2006, entry version 34.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Spirochaetaceae Borrelia Borrelia burgdorferi group.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_BORBU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001179 | AAC67157.1 | - |
| PIR | D70199 | D70199. | |
| HSSP | P23909 | 1NG9 | |
| GenomeReviews | AE000783_GR | BB0797.1 | |
| TIGR | BB0797 | -. | |
| BioCyc | BBUR139:BB0797-MONOMER | -.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35210 / B31;
RX MEDLINE=98065943; PubMed=9403685; DOI=10.1038/37551;
RA Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K.,
RA Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D.,
RA Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J.,
RA Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D.,
RA Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A.,
RA Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K.,
RA Roberts K.M., Hatch B., Smith H.O., Venter J.C.;
RT "Genomic sequence of a Lyme disease spirochaete, Borrelia
RT burgdorferi.";
RL Nature 390:580-586(1997).
Feature:
CHAIN 1 862 DNA mismatch repair protein mutS.
/FTId=PRO_0000115073.
NP_BIND 608 615 ATP (Potential).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 862
MEKNVTPMIR QYLDIKKKYK DAVLFFRVGS FYEMFFDDAI EVSKLLNLTL TKRENVPMCG
VPYHTSKEYI RKLILFDKKV AICEQASNST SGGPLEREVV EVITPGVIID EDFLNDDINN
YLVAISDYKD YYSFSYIDLS TSSLGIMFYE NGFFEKLKRD LEKYSPKEII VSENFYYEYS
EKLNLSRFLI NRVPTWHLDK DIAIKTIKEH FNILGLSSLG FDEEKPYYIS IFLIINHIKN
NLKNLLSNID KIDINNDSSY MFLDDVTQVN LELVKNNNDF SSQYSLYSVL NDCKTAMGKR
LLREFILNPI LNISEINTRL DHVEFFCKNI SLTVTLRETF INIWDIERII SRIQMKRYIK
KDFLFIEKAL SVFFTVKKLF DKHNFDYWNF DKFEEDSISK VYFLINSAIS SAPDELIKRG
YDLKLDNLKD LKINANKYID QYLESERLLS KINNLKIRKT NNRGLFFEVT KSNYAQVPPH
FMESQALNSS KRYKTEKLIS LEVDINNAED NVVAFEQEIF DEIASNVVMH NKVLKKVAEF
FAYIDLVVNF GYLAKKNEYK RPVLTSGKEI LLEKSRHPVV EHYTKNTEIF TENFVRINKE
KYFCLITGPN MAGKSTYLRQ VALITLMAHI GSFVPASKAL IGITDKIFCR IGASDNIAKG
ESTFLVEMNE TANILRNATE KSLIIMDEVG RGTSTNDGLA IAYSIIEYIL EYIKARSLFA
THFHELSSIN HQAFINLSMK IEKQGNDLVF LREVEEKPSL NSYGIYVARI AGLPLRVIDR
ANVILESLVG REGNSCLEFL PHVSSDGNDK EILKNDTDIH IKLNEYLELK NFISNIDINN
ITPFQSIELL NQIVLKVISQ SS