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Description:
ATP-dependent DNA helicase recG (EC 3.6.1.-).
Molecular weight: 79044
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-JUN-1998, sequence version 1.
07-MAR-2006, entry version 35.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Spirochaetaceae Borrelia Borrelia burgdorferi group.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RECG_BORBU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001159 | AAC66942.1 | - |
| PIR | D70172 | D70172. | |
| HSSP | Q9WY48 | 1GM5 | |
| GenomeReviews | AE000783_GR | BB0581.1 | |
| TIGR | BB0581 | -. | |
| BioCyc | BBUR139:BB0581-MONOMER | -.1 | |
| InterPro | IPR001410 | DEAD. | |
| InterPro | IPR011545 | DEAD/DEAH_N. | |
| InterPro | IPR001650 | Helicase_C. | |
| InterPro | IPR004609 | RecG. | |
| Pfam | PF00270 | DEAD | 1. |
| Pfam | PF00271 | Helicase_C | 1. |
| SMART | SM00487 | DEXDc | 1. |
| SMART | SM00490 | HELICc | 1. |
| TIGRFAMs | TIGR00643 | recG | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35210 / B31;
RX MEDLINE=98065943; PubMed=9403685; DOI=10.1038/37551;
RA Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K.,
RA Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D.,
RA Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J.,
RA Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D.,
RA Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A.,
RA Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K.,
RA Roberts K.M., Hatch B., Smith H.O., Venter J.C.;
RT "Genomic sequence of a Lyme disease spirochaete, Borrelia
RT burgdorferi.";
RL Nature 390:580-586(1997).
Feature:
CHAIN 1 686 ATP-dependent DNA helicase recG.
/FTId=PRO_0000102139.
NP_BIND 290 297 ATP (Potential).
MOTIF 391 394 DEQH box.
Comments:
-!- FUNCTION: Critical role in recombination and DNA repair. Help
process Holliday junction intermediates to mature products by
catalyzing branch migration. Has a DNA unwinding activity
characteristic of a DNA helicase with a 3' to 5' polarity. RecG
unwind branched duplex DNA (Y-DNA) (By similarity).
-!- SIMILARITY: Belongs to the helicase family. RecG subfamily.
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Sequence length: 686
MFLHEFEYEL KGIGGLGEKG VERLNNLQIF NVKDLIEFFP VKYEDRQNIQ TFPDFSKVKS
CDMMTVFTVL GHKKFGDSSK KNLKLTVKSI NEEPFEILLF NRAFLENVFK IDKKFYIYSK
FTYNDYSGLW SCSNFDSEVY SDKPERFKKI LPVYSLTEGL TSKKISLYVK EALEYFFKFG
QTDIPRFLIE KYSLLSLSDA LKEIHFPSSL EMLEKAKKTL IYREIFLLQF FSRYRSSKIL
FREKKDLSKD LLEKVVSSLP FELTEDQKIS IDEIFFDLNS SKPMNRLLQG DVGSGKTLVA
LLSGLPLIEA GYQVAFMAPT DLLARQHYDN LSNILAPFNI SMTLLTGSLR KKDKEQALES
IRNGTSGLIV GTHAIFYEST EFKRLAYVII DEQHKFGVVQ REELKNKGEG VDMLLMSATP
IPRSFALTLF GDLEVSFIKT LPKGRLPITT YLARHGNEDK VYEFLRKELL KGHQVYFVYP
LISSSEKFEL KDVNNMCLKL KEVFGEYVVD MLHSKLPSDL KEEIMKNFYS KKVDILVATS
VIEVGIDCPN ATCMVVEHAE RFGLSTLHQI RGRVGRSNLQ SFFFLLYKEP LTSAGKFRLK
TIKENLDGFK IAEEDLRLRG PGNLFGLEQA GYLKLKIANF VDDREIIVLV REELDLFFYD
NSAYDKLDID LLDNLFCSYL NAGRSI