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Description:
Holliday junction ATP-dependent DNA helicase ruvA (EC 3.6.1.-).
Molecular weight: 22688
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
15-DEC-1998, sequence version 2.
07-MAR-2006, entry version 43.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Spirochaetaceae Borrelia Borrelia burgdorferi group.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RUVA_BORBU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | Y08885 | CAA70096.1 | - |
| EMBL | AE001116 | AAC66409.1 | - |
| PIR | G70102 | G70102. | |
| HSSP | P08576 | 1CUK | |
| GenomeReviews | AE000783_GR | BB0023.1 | |
| TIGR | BB0023 | -. | |
| BioCyc | BBUR139:BB0023-MONOMER | -.1 | |
| HAMAP | MF_00031 | - | 1. |
| InterPro | IPR003583 | HHH1_bd. | |
| InterPro | IPR012340 | OB_NA_bd_sub. | |
| InterPro | IPR000085 | RuvA. | |
| Pfam | PF01330 | RuvA_N | 1. |
| ProDom | PD006268 | RuvA | 1. |
| SMART | SM00278 | HhH1 | 2. |
| TIGRFAMs | TIGR00084 | ruvA | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-197.
RC STRAIN=HB19;
RX MEDLINE=98439362; PubMed=9766225; DOI=10.1016/S0923-2508(98)80299-4;
RA Boursaux-Eude C., Margarita D., Belfaiza J., Old I.G.,
RA Saint-Girons I.;
RT "Homologues of helicase genes priA and ruvAB of Borrelia burgdorferi,
RT the Lyme borreliosis agent.";
RL Res. Microbiol. 149:235-245(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35210 / B31;
RX MEDLINE=98065943; PubMed=9403685; DOI=10.1038/37551;
RA Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K.,
RA Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D.,
RA Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J.,
RA Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D.,
RA Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A.,
RA Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K.,
RA Roberts K.M., Hatch B., Smith H.O., Venter J.C.;
RT "Genomic sequence of a Lyme disease spirochaete, Borrelia
RT burgdorferi.";
RL Nature 390:580-586(1997).
Feature:
CHAIN 1 197 Holliday junction ATP-dependent DNA
helicase ruvA.
/FTId=PRO_0000094606.
CONFLICT 103 103 K -> R (in Ref. 1).
Comments:
-!- FUNCTION: The ruvA-ruvB complex in the presence of ATP renatures
cruciform structure in supercoiled DNA with palindromic sequence,
indicating that it may promote strand exchange reactions in
homologous recombination. RuvAB is an helicase that mediates the
Holliday junction migration by localized denaturation and
reannealing. RuvA stimulates, in the presence of DNA, the weak
ATPase activity of ruvB (By similarity).
-!- SUBUNIT: Forms a complex with ruvB.
-!- SIMILARITY: Belongs to the ruvA family.
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Sequence length: 197
MINKIHGKVI EKKESSLVLM TTVFEFELLV SAFCLANFNL SDKVELFTYL YTRENELKLF
GFLNSDEREI FKELIGVSGV GPRAALRVLS NIRYNEFKEA IDKEDIELVS KIKGIGKKMA
GKMFLHLQGK LLINSELEST GLFRFKELEE SIVSMGFDRK IVNSKIREAF NLAEFANLKD
SEKEQFLFKE VLKRISN