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Description:
Holliday junction ATP-dependent DNA helicase ruvB (EC 3.6.1.-).
Molecular weight: 39006
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
01-FEB-1997, sequence version 1.
07-MAR-2006, entry version 41.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Spirochaetaceae Borrelia Borrelia burgdorferi group.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RUVB_BORBU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | Y08885 | CAA70097.1 | - |
| EMBL | AE001116 | AAC66410.1 | - |
| PIR | F70102 | F70102. | |
| HSSP | Q56313 | 1J7K | |
| GenomeReviews | AE000783_GR | BB0022.1 | |
| TIGR | BB0022 | -. | |
| BioCyc | BBUR139:BB0022-MONOMER | -.1 | |
| HAMAP | MF_00016 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR003959 | AAA_ATPase_centr. | |
| InterPro | IPR000641 | CbxX_CfqX. | |
| InterPro | IPR004605 | RuvB. | |
| InterPro | IPR008823 | RuvB_C. | |
| InterPro | IPR008824 | RuvB_N. | |
| InterPro | IPR011991 | Wing_hlx_DNA_bd. | |
| Pfam | PF00004 | AAA | 1. |
| Pfam | PF05491 | RuvB_C | 1. |
| Pfam | PF05496 | RuvB_N | 1. |
| PRINTS | PR00819 | CBXCFQXSUPER. | |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR00635 | ruvB | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; Helicase; Hydrolase; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=HB19;
RX MEDLINE=98439362; PubMed=9766225; DOI=10.1016/S0923-2508(98)80299-4;
RA Boursaux-Eude C., Margarita D., Belfaiza J., Old I.G.,
RA Saint-Girons I.;
RT "Homologues of helicase genes priA and ruvAB of Borrelia burgdorferi,
RT the Lyme borreliosis agent.";
RL Res. Microbiol. 149:235-245(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35210 / B31;
RX MEDLINE=98065943; PubMed=9403685; DOI=10.1038/37551;
RA Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K.,
RA Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D.,
RA Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J.,
RA Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D.,
RA Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A.,
RA Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K.,
RA Roberts K.M., Hatch B., Smith H.O., Venter J.C.;
RT "Genomic sequence of a Lyme disease spirochaete, Borrelia
RT burgdorferi.";
RL Nature 390:580-586(1997).
Feature:
CHAIN 1 347 Holliday junction ATP-dependent DNA
helicase ruvB.
/FTId=PRO_0000165500.
NP_BIND 64 71 ATP (Potential).
Comments:
-!- FUNCTION: The ruvA-ruvB complex in the presence of ATP renatures
cruciform structure in supercoiled DNA with palindromic sequence,
indicating that it may promote strand exchange reactions in
homologous recombination. RuvAB is an helicase that mediates the
Holliday junction migration by localized denaturation and
reannealing (By similarity).
-!- SUBUNIT: Forms a complex with ruvA (By similarity).
-!- SIMILARITY: Belongs to the ruvB family.
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Sequence length: 347
MKDENSISFL SSNENYLYDK SENELRPKVF EDFKGQVNVK ETLSIFIRAS KERDEALDHV
FLSGPPGLGK TTLASIIAFE MNASIKITSA PAFDKPKDII GILTGLDEKS VLFIDEIHRL
RPIIEEMLCI AMEDYELDWV IGQGANARTV RMPLPKFTLI GATTKPGKVT SPLYARFGIT
ARFELYSEIE LVEIIKRNSL ILNIEIEEDA AFLLARSSRG TPRIANRLLR RIRDIAQVTG
SLVITSDIVS IGLEMLRIDG EGLDEQDRNI LRSLILKFNG GPVGVDTLAI SVGETADSLE
DFYEPYLIMK GFISRTHRGR KATEFAYLHL NLEMKEDGLN ENQRVSF