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Description:
Uracil-DNA glycosylase (EC 3.2.2.-) (UDG).
Molecular weight: 25561
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
01-JUN-1998, sequence version 1.
07-MAR-2006, entry version 42.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Spirochaetaceae Borrelia Borrelia burgdorferi group.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG_BORBU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001118 | AAC66430.1 | - |
| EMBL | U57684 | AAB53935.1 | - |
| PIR | E70106 | E70106. | |
| HSSP | P13051 | 1AKZ | |
| GenomeReviews | AE000783_GR | BB0053.1 | |
| TIGR | BB0053 | -. | |
| BioCyc | BBUR139:BB0053-MONOMER | -.1 | |
| HAMAP | MF_00148 | - | 1. |
| InterPro | IPR003249 | U_glycsylse_notp. | |
| InterPro | IPR003250 | U_glycsylse_pox. | |
| InterPro | IPR002043 | UDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| PANTHER | PTHR11264 | U_glycsylse_notp.1 | 1. |
| Pfam | PF03167 | UDG | 1. |
| ProDom | PD001589 | U_glycsylse_notp | 1. |
| ProDom | PD011327 | U_glycsylse_pox | 1. |
| TIGRFAMs | TIGR00628 | ung | 1. |
| PROSITE | PS00130 | U_DNA_GLYCOSYLASE | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35210 / B31;
RX MEDLINE=98065943; PubMed=9403685; DOI=10.1038/37551;
RA Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K.,
RA Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D.,
RA Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J.,
RA Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D.,
RA Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A.,
RA Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K.,
RA Roberts K.M., Hatch B., Smith H.O., Venter J.C.;
RT "Genomic sequence of a Lyme disease spirochaete, Borrelia
RT burgdorferi.";
RL Nature 390:580-586(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-80.
RC STRAIN=ATCC 35210 / B31;
RA Gebbia J.A., Backenson P.B., Anda P., Coleman J.L., Benach J.L.;
RL Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases.
Feature:
CHAIN 1 223 Uracil-DNA glycosylase.
/FTId=PRO_0000176071.
ACT_SITE 67 67 Proton acceptor (By similarity).
CONFLICT 32 32 E -> D (in Ref. 2).
CONFLICT 73 79 NQANGLA -> KPSXWTC (in Ref. 2).
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
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Sequence length: 223
MKVKIEESWK EVLNNEFNKE YFKKLVKFIK HEYKTKNGKI FPPPKLIFNA FNSLPFKDIK
VVIIGQDPYH GKNQANGLAF SVDSKIKIPP SLQNIFKEIE KSLKIKTIPN GDLKRWAIQG
VFLINTILTV EEGKPSSHKA IGWEIFTDEV IKIISKNLKN IVFMLWGNLA RSKKGLIDPT
KHLILETSHP SPYSANNGFL GSNHFSSALD YLKKHNKNII NFQ