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Description:
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A).
Molecular weight: 10579
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-JUN-1998, sequence version 1.
07-MAR-2006, entry version 40.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Spirochaetaceae Borrelia Borrelia burgdorferi group.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRA_BORBU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE001182 | AAC67184.1 | - |
| PIR | D70204 | D70204. | |
| GenomeReviews | AE000783_GR | BB0837.1 | |
| TIGR | BB0837 | -. | |
| BioCyc | BBUR139:BB0837-MONOMER | -.1 | |
| HAMAP | MF_00205 | - | 1. |
| InterPro | IPR003439 | ABC_transp_like. | |
| InterPro | IPR004602 | UvrA_ABC. | |
| Pfam | PF00005 | ABC_tran | 1. |
| ProDom | PD000006 | ABC_transporter | 1. |
| TIGRFAMs | TIGR00630 | uvra | 1. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | 1. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35210 / B31;
RX MEDLINE=98065943; PubMed=9403685; DOI=10.1038/37551;
RA Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K.,
RA Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D.,
RA Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J.,
RA Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D.,
RA Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A.,
RA Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K.,
RA Roberts K.M., Hatch B., Smith H.O., Venter J.C.;
RT "Genomic sequence of a Lyme disease spirochaete, Borrelia
RT burgdorferi.";
RL Nature 390:580-586(1997).
Feature:
CHAIN 1 950 UvrABC system protein A.
/FTId=PRO_0000093036.
DOMAIN 350 599 ABC transporter 1.
DOMAIN 616 947 ABC transporter 2.
NP_BIND 36 43 ATP (Potential).
ZN_FING 260 287 C4-type.
NP_BIND 651 658 ATP (Potential).
ZN_FING 750 776 C4-type.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrA is an ATPase and a DNA-binding
protein. A damage recognition complex composed of 2 uvrA and 2
uvrB subunits scans DNA for abnormalities. When the presence of a
lesion has been verified by uvrB, the uvrA molecules dissociate
(By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrB during the search for
lesions (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily.
-!- SIMILARITY: Contains 2 ABC transporter domains.
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Sequence length: 950
MEKSLKKKII VRGAKEHNLK NVDVDIPKDG LVVISGKSGS GKSSLAFDTI FAEGQRRYME
SVSAYARQFL GVMKKPNVDY IDGLSPSIAI EQRTISNNPR STVGTITEIY DYYRLIFAKI
GKAYCPNDGR LIEEQSLDKI VNTILSYSEG SKVILFAPIV RGSKGSHKKV LEKILNQGFN
RVRINSEDYL IEDALNLNLH KNKKHTIEII VDRIKLGNNV RVRLAESIET SLAVSNGYLR
VEIDNDLEKI DKLFTEHNSC PLCGFSLPLI EPRLFSFNSP FGACSECSGL GVTLEFDFES
ICPDTSLSFN DDAFLTFKTS SSWSVAIFKG LAKHYNFDLN TPIKDIPDKV LKQILYGSNE
KIDFIYQSKE MEAKELDGGF HYSKTFEGLL PLLKRRYLAT ESESTKIFYE NLMSKKICNS
CKGKRLSVGA LTVKINGKDI QDLTNLSVFD SYVFFENLQL DMVDEKISKE ILKEIKSRLK
FLIDVGLSYL YLNRISGSLS GGEAQRIRLA TQIGSALSGV IYVLDEPSIG LHQRDNEKLI
STLVNLKNLG NTVIVVEHDE QTLRTADYII DMGPGAGILG GEIVAKGALI DILNSKNSLT
GQYLSGKFKI DVPSSRRKAD KGEILLLGSN KNNLKNIDLS IPLGVFTVIT GVSGSGKSTL
LNEVLYPALD SRLKLNEKYC DGFKDIVGYE KIDKIIQINQ KPIGRTSRSN PATYVGFFTE
IRELFAKLPD AKSRGFKAGR FSFNVKGGRC EKCQGDGYLN IQMHFLPDVF VPCDLCKGKK
FNEETLEVRY KGKNIHDVLE MSVFEASKFF ENVPKISHYL KFLIEVGLEY IKLGQSATTL
SGGEAQRIKL AFELSKKSTG KTFYIIDEPT TGLHFDDIKK LLEVLQRLVS NGNTVVLIEH
NLDVIKQADY IIDLGPDGGL AGGNIVVSGI PEEVAKCENS YTGMFLKNLL