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Description:
DNA mismatch repair protein mutL.
Molecular weight: 70431
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
07-MAR-2006, entry version 43.
Phylogenetic order:
Bacteria Firmicutes Bacillales Bacillaceae Bacillus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_BACSU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | U27343 | AAB19236.1 | - |
| EMBL | Z99112 | CAB13578.1 | - |
| PIR | A69663 | A69663. | |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | AL009126_GR | BSU17050.1 | |
| SubtiList | BG11402 | mutL. | |
| BioCyc | BSUB1423:BSU1706-MONOMER | -.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX MEDLINE=96349107; PubMed=8760914;
RA Ginetti F., Perego M., Albertini A.M., Galizzi A.;
RT "Bacillus subtilis mutS mutL operon: identification, nucleotide
RT sequence and mutagenesis.";
RL Microbiology 142:2021-2029(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX MEDLINE=98044033; PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G.,
RA Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S.,
RA Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S.,
RA Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M.,
RA Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A.,
RA Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T.,
RA Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D.,
RA Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N.,
RA Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G.,
RA Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A.,
RA Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M.,
RA Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M.,
RA Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S.,
RA Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G.,
RA Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B.,
RA Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R.,
RA Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P.,
RA Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H.,
RA Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P.,
RA Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F.,
RA Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H.,
RA Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
Feature:
CHAIN 1 627 DNA mismatch repair protein mutL.
/FTId=PRO_0000177927.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 627
MAKVIQLSDE LSNKIAAGEV VERPASVVKE LVENAIDADS TVIEIDIEEA GLASIRVLDN
GEGMENEDCK RAFRRHATSK IKDENDLFRV RTLGFRGEAL PSIASVSHLE ITTSTGEGAG
TKLVLQGGNI ISESRSSSRK GTEIVVSNLF FNTPARLKYM KTVHTELGNI TDVVNRIALA
HPEVSIRLRH HGKNLLQTNG NGDVRHVLAA IYGTAVAKKM LPLHVSSLDF EVKGYIALPE
ITRASRNYMS SVVNGRYIKN FPLVKAVHEG YHTLLPIGRH PITFIEITMD PILVDVNVHP
SKLEVRLSKE TELHDLIRDG IKDVFKQQQL IPSAQVPKKS APAIKNEQQF ITFDEKPPEK
KVPEKSTAPS YSPMKLSSVV KEPVDAEEKL PPLQFDAPPI VDQEQTLEVS DVSAEQPETF
EQECHEEQPQ PASDRVPIMY PIGQMHGTYI LAQNENGLYI IDQHAAQERI KYEYFREKVG
EVEPEVQEMI VPLTFHYSTN EALIIEQHKQ ELESVGVFLE SFGSNSYIVR CHPAWFPKGE
EAELIEEIIQ QVLDSKNIDI KKLREEAAIM MSCKGSIKAN RHLRNDEIKA LLDDLRSTSD
PFTCPHGRPI IIHHSTYEME KMFKRVM