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Description:
DNA mismatch repair protein mutS.
Molecular weight: 97591
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
30-MAY-2000, sequence version 2.
07-MAR-2006, entry version 43.
Phylogenetic order:
Bacteria Firmicutes Bacillales Bacillaceae Bacillus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_BACSU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | U27343 | AAB19235.1 | ALT_INIT |
| EMBL | Z99112 | CAB13577.1 | - |
| PIR | C69663 | C69663. | |
| HSSP | P23909 | 1NG9 | |
| GenomeReviews | AL009126_GR | BSU17040.1 | |
| SubtiList | BG11403 | mutS. | |
| BioCyc | BSUB1423:BSU1705-MONOMER | -.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX MEDLINE=96349107; PubMed=8760914;
RA Ginetti F., Perego M., Albertini A.M., Galizzi A.;
RT "Bacillus subtilis mutS mutL operon: identification, nucleotide
RT sequence and mutagenesis.";
RL Microbiology 142:2021-2029(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX MEDLINE=98044033; PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G.,
RA Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S.,
RA Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S.,
RA Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M.,
RA Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A.,
RA Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T.,
RA Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D.,
RA Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N.,
RA Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G.,
RA Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A.,
RA Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M.,
RA Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M.,
RA Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S.,
RA Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G.,
RA Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B.,
RA Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R.,
RA Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P.,
RA Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H.,
RA Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P.,
RA Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F.,
RA Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H.,
RA Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
Feature:
CHAIN 1 858 DNA mismatch repair protein mutS.
/FTId=PRO_0000115070.
NP_BIND 602 609 ATP (Potential).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 858
MAGYTPMIQQ YLKIKAEHQD AFLFFRLGDF YEMFFEDAKK ASQELEITLT SRDGGAAEKI
PMCGVPYHSA SAYIEQLIKK GYKVAICEQT EDPKAAKGVV KREVVQLITP GTVMDGKGIH
ESENNFIASV SACSNGYGLA LSDLTTGENL AVLIERLEDV ISEIYSVGAR EIVVSGSLDA
DTVAQLRERC GATISIEDGE TDEHVTIIEH LNNEDITKTF LRLYTYLKRT QKRSLDHLQP
VQVYELEEAM KIDLYSKRNL ELTETIRSKN KKGSLLWLLD ETKTAMGGRL LKQWIDRPLI
RVNQIEERQE MVETLMSHFF EREDLRERLK EVYDLERLAG RVAFGNVNAR DLIQLKESLK
QVPGIKQLVA SLAHDKAKER AKRIDPCGDV LELLEEALYE NPPLSVKEGN LIKDGYNQKL
DEYRDASRNG KDWIARLEQQ EREYTGIRSL KVGFNKVFGY YIEVTKANLH LLEEGRYERN
ETLTNAERYI TPELKEKEAL ILEAENNICE LEYELFTELR EKVKQYIPRL QQLAKQMSEL
DALQCFATIS ENRHYTKPEF SKDEVEVIEG RHPVVEKVMD SQEYVPNNCM MGDNRQMLLI
TGPNMSGKST YMRQIALISI MAQIGCFVPA KKAVLPIFDQ IFTRIGAADD LISGQSTFMV
EMLEAKNAIV NATKNSLILF DEIGRGTSTY DGMALAQAII EYVHDHIGAK TLFSTHYHEL
TVLEDKLPQL KNVHVRAEEY NGTVVFLHQI KEGAADKSYG IHVAQLAELP GDLIARAQDI
LKELEHSGNK PEVPVQKPQV KEEPAQLSFF DEAEKPAETP KLSKKEKQVI DAFKSLNILD
MTPLEAMNEM YKLQKKLH