Protein data for PCRA_BACSU:

Description:
ATP-dependent DNA helicase pcrA (EC 3.6.1.-).

Molecular weight: 83555

View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )

Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-JAN-1998, sequence version 1.
07-MAR-2006, entry version 43.

Phylogenetic order:
Bacteria Firmicutes Bacillales Bacillaceae Bacillus.

To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html

Links to references in other databases for protein PCRA_BACSU:

Database Pointer Add. info#1 Add. info#2
EMBL Y15254 CAA75552.1 -
EMBL Z99107 CAB12481.1 -
PIR E69794 E69794.
HSSP P56255 1PJR
SMR O34580 1-648.1
GenomeReviews AL009126_GR BSU06610.1
SubtiList BG12834 pcrA.
BioCyc BSUB1423:BSU0662-MONOMER -.1
LinkHub O34580 -.1
InterPro IPR005751 PcrA.
InterPro IPR000212 UvrD-helicase.
PANTHER PTHR11070 UvrD-helicase.1 1.
Pfam PF00580 UvrD-helicase 1.
TIGRFAMs TIGR01073 pcrA 1.

General information about the databases mentioned above

Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding.

References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX MEDLINE=98367141; PubMed=9701819;
RA Petit M.-A., Dervyn E., Rose M., Entian K.-D., McGovern S.,
RA Ehrlich S.D., Bruand C.;
RT "PcrA is an essential DNA helicase of Bacillus subtilis fulfilling
RT functions both in repair and rolling-circle replication.";
RL Mol. Microbiol. 29:261-273(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX MEDLINE=98044033; PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G.,
RA Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S.,
RA Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S.,
RA Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M.,
RA Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A.,
RA Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T.,
RA Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D.,
RA Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N.,
RA Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G.,
RA Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A.,
RA Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M.,
RA Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M.,
RA Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S.,
RA Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G.,
RA Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B.,
RA Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R.,
RA Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P.,
RA Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H.,
RA Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P.,
RA Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F.,
RA Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H.,
RA Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).

Feature:
CHAIN 1 739 ATP-dependent DNA helicase pcrA.
/FTId=PRO_0000102051.
NP_BIND 31 38 ATP (Potential).

Comments:
-!- FUNCTION: DNA helicase used for plasmid rolling-circle replication
and also involved in UV repair.
-!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
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Sequence length: 739

     MNYISNQLLS GLNPVQQEAV KTTDGPLLLM AGAGSGKTRV LTHRIAYLMA EKHVAPWNIL
     AITFTNKAAR EMKERVESIL GPGADDIWIS TFHSMCVRIL RRDIDRIGIN RNFSILDTAD
     QLSVIKGILK ERNLDPKKFD PRSILGTISS AKNELTEPEE FSKVAGGYYD QVVSDVYADY
     QKKLLKNQSL DFDDLIMTTI KLFDRVPEVL EFYQRKFQYI HVDEYQDTNR AQYMLVKQLA
     ERFQNLCVVG DSDQSIYRWR GADITNILSF EKDYPNASVI LLEQNYRSTK RILRAANEVI
     KNNSNRKPKN LWTENDEGIK ISYYRGDNEF GEGQFVAGKI HQLHSTGKRK LSDIAILYRT
     NAQSRVIEET LLKAGLNYNI VGGTKFYDRK EIKDILAYLR LVSNPDDDIS FTRIVNVPKR
     GVGATSLEKI ASYAAINGLS FFQAIQQVDF IGVSAKAANA LDSFRQMIEN LTNMQDYLSI
     TELTEEILDK TEYREMLKAE KSIEAQSRLE NIDEFLSVTK NFEQKSEDKT LVAFLTDLAL
     IADIDQLDQK EEESGGKDAI TLMTLHAAKG LEFPVVFLMG LEEGVFPHSR SLMEEAEMEE
     ERRLAYVGIT RAEQELYLTN AKMRTLFGRT NMNPESRFIA EIPDDLLENL NEKKETRATS
     ARKMQPRRGP VSRPVSYASK TGGDTLNWAV GDKAGHKKWG TGTVVSVKGE GEGTELDIAF
     PSPVGVKRLL AAFAPIEKQ

Back

Database	Pointer	Add. info#1	Add. info#2
EMBL	Y15254	CAA75552.1	-
EMBL	Z99107	CAB12481.1	-
PIR	E69794	E69794.
HSSP	P56255	1PJR
SMR	O34580	1-648.1
GenomeReviews	AL009126_GR	BSU06610.1
SubtiList	BG12834	pcrA.
BioCyc	BSUB1423:BSU0662-MONOMER	-.1
LinkHub	O34580	-.1
InterPro	IPR005751	PcrA.
InterPro	IPR000212	UvrD-helicase.
PANTHER	PTHR11070	UvrD-helicase.1	1.
Pfam	PF00580	UvrD-helicase	1.
TIGRFAMs	TIGR01073	pcrA	1.