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Description:
ATP-dependent DNA helicase recG (EC 3.6.1.-).
Molecular weight: 78141
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-JAN-1998, sequence version 1.
07-MAR-2006, entry version 42.
Phylogenetic order:
Bacteria Firmicutes Bacillales Bacillaceae Bacillus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RECG_BACSU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | Y13937 | CAA74246.1 | - |
| EMBL | Z99112 | CAB13460.1 | - |
| PIR | H69879 | H69879. | |
| HSSP | Q9WY48 | 1GM5 | |
| GenomeReviews | AL009126_GR | BSU15870.1 | |
| SubtiList | BG13399 | recG. | |
| BioCyc | BSUB1423:BSU1588-MONOMER | -.1 | |
| InterPro | IPR001410 | DEAD. | |
| InterPro | IPR011545 | DEAD/DEAH_N. | |
| InterPro | IPR001650 | Helicase_C. | |
| InterPro | IPR004365 | OB_tRNA_NA_bd. | |
| InterPro | IPR004609 | RecG. | |
| Pfam | PF00270 | DEAD | 1. |
| Pfam | PF00271 | Helicase_C | 1. |
| Pfam | PF01336 | tRNA_anti | 1. |
| SMART | SM00487 | DEXDc | 1. |
| SMART | SM00490 | HELICc | 1. |
| TIGRFAMs | TIGR00643 | recG | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX MEDLINE=98195738; PubMed=9534248;
RA Foulger D., Errington J.;
RT "A 28 kbp segment from the spoVM region of the Bacillus subtilis 168
RT genome.";
RL Microbiology 144:801-805(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX MEDLINE=98044033; PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G.,
RA Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S.,
RA Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S.,
RA Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M.,
RA Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A.,
RA Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T.,
RA Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D.,
RA Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N.,
RA Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G.,
RA Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A.,
RA Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M.,
RA Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M.,
RA Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S.,
RA Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G.,
RA Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B.,
RA Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R.,
RA Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P.,
RA Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H.,
RA Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P.,
RA Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F.,
RA Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H.,
RA Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
Feature:
CHAIN 1 682 ATP-dependent DNA helicase recG.
/FTId=PRO_0000102138.
NP_BIND 284 291 ATP (Potential).
MOTIF 385 388 DEQH box.
Comments:
-!- FUNCTION: Critical role in recombination and DNA repair. Help
process Holliday junction intermediates to mature products by
catalyzing branch migration. Has a DNA unwinding activity
characteristic of a DNA helicase with a 3' to 5' polarity. RecG
unwind branched duplex DNA (Y-DNA) (By similarity).
-!- SIMILARITY: Belongs to the helicase family. RecG subfamily.
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Sequence length: 682
MKQHQQTSIA NIKGIGPETE KTLNELGIYD ISDLLNYFPY RYDDYELRDL EEVKHDERVT
VEGKVHSEPS LTYYGKKRNR LTFRLLVGHY LITAVCFNRP YLKKKLSLGS VVTVSGKWDK
HRQTISVQEL KNGPHQEDKS IEPVYSVKEN VTVKMMRRFI QQALTQYADS LPDPLPEKLR
KSYKLPDYYQ ALKAMHQPET REALKLARRR FVYEEFLLFQ LKMQAFRKAE REQTQGIRQR
FSNEELMRFI KSLPFPLTNA QSRVLREITA DMSSPYRMNR LLQGDVGSGK TAVAAIALYA
AILSGYQGAL MVPTEILAEQ HADSLVSLFE KWDVSVALLT SSVKGKRRKE LLERLAAGEI
DILVGTHALI QDEVEFKALS LVITDEQHRF GVEQRKKLRN KGQDPDVLFM TATPIPRTLA
ITVFGEMDVS VIDEMPAGRK RIETYWVKHD MLDRILAFVE KELKQGRQAY IICPLIEESD
KLDVQNAIDV YNMLSDIFRG KWNVGLMHGK LHSDEKDQVM REFSANHCQI LVSTTVVEVG
VNVPNATIMV IYDADRFGLS QLHQLRGRVG RGEHQSFCIL MADPKSETGK ERMRIMSETN
DGFELSEKDL ELRGPGDFFG KKQSGMPEFK VADMVHDYRA LETARQDAAN LVASDAFWKE
PEYAVLRDEL LKSGVMDGEK LS